碳化硅二极管作为质子UHDR剂量测定中具有成本效益的主动探测器的特性

IF 3.2 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Medical physics Pub Date : 2025-07-15 DOI:10.1002/mp.17986
Ivan Lopez Paz, Celeste Fleta, Paula Ibáñez, Ángela Henao, Daniel Sanchez-Parcerisa, Adrián Zazpe, Ines del Monte-Garcia, Consuelo Guardiola
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引用次数: 0

摘要

背景质子治疗可以更好地定位肿瘤中的剂量分布。此外,可以利用FLASH效应,通过使用超高剂量率(UHDR)的短脉冲治疗来减少对健康组织的毒性。如此强烈的辐射条件下,用于剂量测定的主动探测器的选择有限。目的提出碳化硅基二极管作为一种具有成本效益的替代金刚石探测器用于超高dr剂量测定。方法将巴塞罗那微电子研究所(IMB-CNM)设计和制造的两个新型SiC二极管暴露在20 μ s $\mu{\rm s}$质子低能脉冲下,每脉冲高达25 Gy,以验证该技术在材料微量分析中心(CMAM) UHDR辐射下的功能。设施。单个二极管的响应与校准的EBT4放射性致色膜测量的每脉冲剂量相关。同样,安装在电动舞台系统上的2 × $\ × $ 2剂量计矩阵被用作正在建造的大型阵列剂量监视器的概念验证,通过扫描其每个像素的响应作为相对于光束的位置的函数,与校准的放射性致色膜进行比较。最后,将同一器件暴露在不同的脉冲长度下,同时连接到一个电流-电压放大器和一个示波器,以测量脉冲结构。结果首先,单二极管具有良好的剂量率线性。即使在每脉冲最高剂量(DPP)为25 Gy时,也未观察到饱和迹象。即使在52kgy的7mev质子过度暴露后也观察到这一点,尽管其响应降低到最初测量值的31%。其次,像素化探测器观测到的光束轮廓与参考测量结果一致。最后,像素观察到的脉冲全宽半最大值与光束的脉冲宽度具有良好的相关性。结论IMB-CNM开发的SiC探测器即使在低能质子(7 MeV)的情况下,也能够承受并准确测量FLASH兼容光束特性下的剂量。像素化设备显示了一个有希望的结果,为质量保证的全阵列监测,以及时间分辨脉冲测量的能力,后者经过优化的电子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterization of silicon carbide diodes as cost-effective active detectors for proton UHDR dosimetry

Background

Proton therapy allows for better localization of the dose distribution in the tumor. In addition, the FLASH effect can be exploited to reduce the toxicity to healthy tissue by using short-pulsed treatment at ultra-high dose rates (UHDR). Such intense radiation conditions have limited options for active detectors for dosimetry.

Purpose

Silicon carbide-based diodes are proposed as a cost-effective alternative to diamond detectors for dosimetry in UHDR.

Methods

Two new SiC diodes designed and fabricated at the Institute of Microelectronics of Barcelona (IMB-CNM) were exposed to 20  μ s $\mu{\rm s}$ proton low-energy pulses with up to 25 Gy per pulse to verify the capability of this technology to function under UHDR radiation at the Center for Microanalysis of Materials (CMAM) facility. The response of a single diode was correlated to the dose per pulse measured with calibrated EBT4 radiochromic films. Likewise, a 2  × $\times$  2 dosimeter matrix mounted on a motorized stage system was used as a proof-of-concept for a large array dose monitor under construction, by scanning the response of each of its pixels as a function of position with respect to the beam, compared against calibrated radiochromic films. Finally, the same device was exposed to varying pulse lengths, while connected to a current-to-voltage amplifier and an oscilloscope in order to measure the pulse structure.

Results

First, the single diode showed a good dose rate linearity. No indication of saturation was observed even at the highest dose per pulse (DPP) of 25 Gy. This was observed even after over-exposure of 52 kGy of 7 MeV protons, although its response lowered to 31% of the initially measured value. Second, the beam profiles observed by the pixelated detector were consistent with those of the reference measurements. Finally, the full width half maximums of the pulses observed by the pixels show good correlation with the pulse width of the beam.

Conclusions

The SiC detectors developed at IMB-CNM were able to withstand and accurately measure the dose under FLASH compatible beam characteristics, even in the case of low-energy protons (7 MeV). The pixelated device showed promising results for a full array monitor for quality assurance, and the capability of time-resolved pulse measurements, the latter after optimization of the electronics.

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来源期刊
Medical physics
Medical physics 医学-核医学
CiteScore
6.80
自引率
15.80%
发文量
660
审稿时长
1.7 months
期刊介绍: Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.
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