舞蹈/音乐和冥想对轻度/中度帕金森病进展的影响：一项单盲随机对照先导研究

IF 1.8 Q3 CLINICAL NEUROLOGY

Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI:10.1016/j.prdoa.2025.100366

Paresh K. Doshi , Bhagyashree Mehrotra , Neha Rai , M.R. Rajani , Aparna Budhakar , Ritika Aggarwal , Mona Thomas , Sampada Patole , Raj V. Agarbattiwala

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引用次数: 0

摘要

帕金森病（PD）严重损害运动和认知功能，降低生活质量。非药物干预，如舞蹈/音乐疗法结合冥想，可能在控制PD症状方面提供潜在的益处。方法于2023年3月至8月进行一项平行、单盲、随机、对照的先导研究，随访6个月。30例轻至中度PD患者，年龄在80岁以下，有参与能力。排除标准为深部脑刺激和高跌倒风险。干预组接受舞蹈/音乐治疗和冥想课程，而对照组继续常规活动。两组患者的用药情况保持不变。主要结局是UPDRS I-III和PDQ-39评分的变化。次要结果包括简易精神状态检查、贝克抑郁量表、帕金森焦虑量表、帕金森病冲动性强迫症量表、伯格平衡测试、Time Up and Go测试、帕金森病护理者问卷（PDQ-Carer）、扎里特-照顾者负担访谈（ZBI）。结果共分析受试者28例，其中干预组15例，对照组13例。干预组UPDRS I-III评分显著改善{差异8分，P = 0.013} （n = 15）。干预组患者的PDQ-39评分较对照组有所改善，降低6.82分，P = 0.0057。干预组护理人员的PDQ-Carer评分（1.5分，P = 0.008）和ZBI评分（1.0分，P = 0.005）均显著降低。其他次要结局指标无显著变化。结论：研究结果显示了这些非药物干预的潜在益处，值得进行更广泛的研究。

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Impact of dance/music and meditation on the progression of Parkinson’s disease with mild/ moderate severity: a single-blinded randomized controlled pilot study

Background

Parkinson’s disease (PD) significantly impairs motor and cognitive functions, reducing quality of life. Non-pharmacological interventions, such as dance/music therapy combined with meditation, may offer potential benefits in managing symptoms of PD.

Methods

A parallel, single-blinded, randomized, controlled pilot study was conducted from March to August 2023 with a six-month follow-up. Thirty patients with mild to moderate PD under 80 years and capable of participating were included. Exclusion criteria were deep brain stimulation and high fall risk. The intervention group received dance/music therapy with meditation sessions, while the control group continued regular activities. Medications remained unchanged in both groups. Primary outcomes were changes in UPDRS I-III and PDQ-39 scores. Secondary outcomes included a mini-mental state examination, Beck’s Depression Inventory, Parkinson’s Anxiety Scale, Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale, Berg Balance Test, Time Up and Go Test, and Parkinson’s disease Questionnaire-Carer (PDQ-Carer), Zarit-Caregiver Burden Interview (ZBI).

Results

Twenty-eight participants were analyzed, with 15 in the intervention group and 13 in the control group. Significant improvement {difference of 8 points, P = 0.013} was noted in UPDRS I-III scores in the intervention group (n = 15). PDQ-39 scores improved in the intervention group {6.82 points reduction, P = 0.0057}. Caregivers in the intervention group showed a significant decrease in PDQ-Carer (1.5 points, P = 0.008) and ZBI scores (1.0 points, P = 0.005). There were no significant changes in other secondary outcome measures.