{"title":"诊断上具有挑战性的案例：两种人畜共患病的共存。","authors":"Melike Törüyenler-Coşkunpınar, İrem Akdemir, Seher Yüksel, Nermin Aras, Meltem Kurt-Yüksel, Alpay Azap","doi":"10.36519/idcm.2025.501","DOIUrl":null,"url":null,"abstract":"<p><p>A male patient presented with fever, cytopenia, and hepatosplenomegaly. The patient's <i>Brucella</i> tube agglutination test was positive at titers 1:640. Due to the lack of response to brucellosis treatment, additional tests were performed. <i>Leishmania</i> amastigotes were seen in the second bone marrow biopsy preparations. <i>Leishmania</i> PCR was positive, and visceral leishmaniasis (VL) was diagnosed. Here, we present a case of VL and brucellosis coinfection that presented with B symptoms (fever, night sweats, and weight loss) and cytopenia and was difficult to diagnose.</p>","PeriodicalId":519881,"journal":{"name":"Infectious diseases & clinical microbiology","volume":"7 2","pages":"214-219"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255313/pdf/","citationCount":"0","resultStr":"{\"title\":\"Diagnostically Challenging Case: Coexistence of Two Zoonoses.\",\"authors\":\"Melike Törüyenler-Coşkunpınar, İrem Akdemir, Seher Yüksel, Nermin Aras, Meltem Kurt-Yüksel, Alpay Azap\",\"doi\":\"10.36519/idcm.2025.501\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A male patient presented with fever, cytopenia, and hepatosplenomegaly. The patient's <i>Brucella</i> tube agglutination test was positive at titers 1:640. Due to the lack of response to brucellosis treatment, additional tests were performed. <i>Leishmania</i> amastigotes were seen in the second bone marrow biopsy preparations. <i>Leishmania</i> PCR was positive, and visceral leishmaniasis (VL) was diagnosed. Here, we present a case of VL and brucellosis coinfection that presented with B symptoms (fever, night sweats, and weight loss) and cytopenia and was difficult to diagnose.</p>\",\"PeriodicalId\":519881,\"journal\":{\"name\":\"Infectious diseases & clinical microbiology\",\"volume\":\"7 2\",\"pages\":\"214-219\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255313/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infectious diseases & clinical microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36519/idcm.2025.501\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious diseases & clinical microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36519/idcm.2025.501","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Diagnostically Challenging Case: Coexistence of Two Zoonoses.
A male patient presented with fever, cytopenia, and hepatosplenomegaly. The patient's Brucella tube agglutination test was positive at titers 1:640. Due to the lack of response to brucellosis treatment, additional tests were performed. Leishmania amastigotes were seen in the second bone marrow biopsy preparations. Leishmania PCR was positive, and visceral leishmaniasis (VL) was diagnosed. Here, we present a case of VL and brucellosis coinfection that presented with B symptoms (fever, night sweats, and weight loss) and cytopenia and was difficult to diagnose.
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