Clinical and Sonographic Assessment of Carboxytherapy Efficacy in Treatment of Skin Aging: A 2-split Randomized Clinical Trial.

Introduction: Aging is a continuous and irreversible process which affects the skin. During the aging process, intrinsic progressive degenerative changes in the skin impair its structure, which makes it prone to different dermatoses, resulting in impaired quality of life in the elderly.

Objective: Carboxytherapy is considered as a safe, minimally invasive modality applied for skin rejuvenation, restoration, and recondition. Herein, we have assessed the efficacy of carboxytherapy in the treatment of skin aging through clinical and sonographic studies.

Materials and methods: Our study was a prospective 2-split clinical trial in which the efficacy of carboxytherapy was assessed in the treatment of abdominal skin aging through clinical and sonographic evaluations.

Results: Twenty-eight patients with skin-intrinsic aging manifestations in the abdomen completed the study. Their mean age was 44.13 years. The mean weight, BMI, and waist circumference of the subjects significantly decreased after the treatment. The clinical subjective and objective evaluations revealed statistically significant improvement of skin wrinkles, laxity, and skin pigmentation and overall satisfaction by carboxytherapy. Upon sonographic investigation, a significant increase in epidermis and dermis thickness was observed. No significant side-effect was reported by the subjects.