Micaela Dines, Adriana Bulacia, Paloma Bamondez, Irene Luis Vega, Micaela Montenegro, Pablo Germán Díaz, Paula Oyhamburu, Ana Laura Ramos, Florencia Ambrosio, Gustavo Vázquez
{"title":"亚麻醉剂量的氯胺酮输注治疗严重耐药抑郁症：阿根廷一家公立医院的实施方案。","authors":"Micaela Dines, Adriana Bulacia, Paloma Bamondez, Irene Luis Vega, Micaela Montenegro, Pablo Germán Díaz, Paula Oyhamburu, Ana Laura Ramos, Florencia Ambrosio, Gustavo Vázquez","doi":"10.53680/vertex.v36i168.832","DOIUrl":null,"url":null,"abstract":"<p><p>Treatment-resistant major depression (TRD) poses a significant challenge in psychiatry due to the limited response to conventional therapies. Subanesthetic dose intravenous (IV) ketamine has emerged as an effective therapeutic option, providing rapid effects on depressive and suicidal symptoms. This article outlines the ketamine infusion protocol implemented in a general hospital, following international guidelines. Inclusion and exclusion criteria, dosage, administration procedure, and patient monitoring. Additionally, adverse effects and safety considerations. The implementation of this protocol optimizes the use of ketamine in TRD, ensuring both efficacy and safety.</p>","PeriodicalId":75297,"journal":{"name":"Vertex (Buenos Aires, Argentina)","volume":"36 168, abr.- jun.","pages":"33-38"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Subanesthetic Dose Ketamine Infusions for Treatment-Resistant Major Depression: An Application Protocol at a Public Hospital in Argentina\",\"authors\":\"Micaela Dines, Adriana Bulacia, Paloma Bamondez, Irene Luis Vega, Micaela Montenegro, Pablo Germán Díaz, Paula Oyhamburu, Ana Laura Ramos, Florencia Ambrosio, Gustavo Vázquez\",\"doi\":\"10.53680/vertex.v36i168.832\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Treatment-resistant major depression (TRD) poses a significant challenge in psychiatry due to the limited response to conventional therapies. Subanesthetic dose intravenous (IV) ketamine has emerged as an effective therapeutic option, providing rapid effects on depressive and suicidal symptoms. This article outlines the ketamine infusion protocol implemented in a general hospital, following international guidelines. Inclusion and exclusion criteria, dosage, administration procedure, and patient monitoring. Additionally, adverse effects and safety considerations. The implementation of this protocol optimizes the use of ketamine in TRD, ensuring both efficacy and safety.</p>\",\"PeriodicalId\":75297,\"journal\":{\"name\":\"Vertex (Buenos Aires, Argentina)\",\"volume\":\"36 168, abr.- jun.\",\"pages\":\"33-38\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vertex (Buenos Aires, Argentina)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.53680/vertex.v36i168.832\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vertex (Buenos Aires, Argentina)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53680/vertex.v36i168.832","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Subanesthetic Dose Ketamine Infusions for Treatment-Resistant Major Depression: An Application Protocol at a Public Hospital in Argentina
Treatment-resistant major depression (TRD) poses a significant challenge in psychiatry due to the limited response to conventional therapies. Subanesthetic dose intravenous (IV) ketamine has emerged as an effective therapeutic option, providing rapid effects on depressive and suicidal symptoms. This article outlines the ketamine infusion protocol implemented in a general hospital, following international guidelines. Inclusion and exclusion criteria, dosage, administration procedure, and patient monitoring. Additionally, adverse effects and safety considerations. The implementation of this protocol optimizes the use of ketamine in TRD, ensuring both efficacy and safety.
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