细胞凝聚启动器官发生:肌动蛋白动力学在细胞超自组织过程中的作用。

IF 6.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jun-Xi He, Bing-Dong Sui, Yan Jin, Chen-Xi Zheng, Fang Jin
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引用次数: 0

摘要

复杂组织结构的出现,均质干细胞凝聚物仍然是发育生物学的一个中心谜。虽然生物化学信号梯度长期以来一直主导着器官模式的解释,但组织尺度力和驱动对称破缺的热力学约束之间的机制相互作用仍未得到解决。这篇综述揭示了超细胞肌动蛋白网络作为机械化学集成商,建立发育的张拉整体结构,其中布朗棘轮驱动的聚合产生图案应力场来指导凝聚层。该范式的核心是肌动蛋白分支的动态重塑,它通过力调节的封顶动力学和角度重定向将机械负荷转化为自适应网络架构。这种可塑性使流体到固体的相变成为可能,通过粘弹性微域的形成稳定器官原基。至关重要的是,这些生物物理过程在功能上与代谢重编程事件耦合,其中细胞骨架菌株调节糖酵解通量和核机械转导途径,为分化决策提供信息,在组织力学和细胞命运规范之间形成反馈回路。基于这些见解,我们认为当前类器官自组织的局限性可能源于肌动蛋白介导的机械相干性的不完全重构,而异质间质凝聚动力学的建模为解码自组织轨迹提供了一个战略框架,将发育原则与再生设计联系起来。通过综合从分子生物物理学到组织力学的进展,这项工作重新定义了器官发生,而不是作为分子命令的层次结构,而是作为生化,机械和热力学约束共同进化以塑造生命结构的新兴连续体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cell condensation initiates organogenesis: the role of actin dynamics in supracellular self-organizing process.

Cell condensation initiates organogenesis: the role of actin dynamics in supracellular self-organizing process.

Cell condensation initiates organogenesis: the role of actin dynamics in supracellular self-organizing process.

The emergence of complex tissue architectures from homogeneous stem cell condensates persists as a central enigma in developmental biology. While biochemical signaling gradients have long dominated explanations of organ patterning, the mechanistic interplay between tissue-scale forces and thermodynamic constraints in driving symmetry breaking remains unresolved. This review unveils supracellular actin networks as mechanochemical integrators that establish developmental tensegrity structures, wherein Brownian ratchet-driven polymerization generates patterned stress fields to guide condensate stratification. Central to this paradigm is the dynamic remodeling of actin branches, which transduce mechanical loads into adaptive network architectures through force-modulated capping kinetics and angular reorientation. Such plasticity enables fluid-to-solid phase transitions, stabilizing organ primordia through viscoelastic microdomain formation. Crucially, these biophysical processes are functionally coupled with metabolic reprogramming events, where cytoskeletal strain modulates glycolytic flux and nuclear mechanotransduction pathways to inform differentiation decisions, forging a feedback loop between tissue mechanics and cellular fate specification. Building on these insights, we argue that limitations in current organoid self-organization may originate from incomplete reconstitution of actin-mediated mechanical coherence, and modeling of heterogeneous mesenchymal condensation dynamics offers a strategic framework to decode self-organization trajectories, bridging developmental principles with regenerative design. By synthesizing advances from molecular biophysics to tissue mechanics, this work reframes organogenesis not as a hierarchy of molecular commands, but as an emergent continuum where biochemical, mechanical, and thermodynamic constraints coevolve to sculpt living architectures.

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来源期刊
Cell and Bioscience
Cell and Bioscience BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
10.70
自引率
0.00%
发文量
187
审稿时长
>12 weeks
期刊介绍: Cell and Bioscience, the official journal of the Society of Chinese Bioscientists in America, is an open access, peer-reviewed journal that encompasses all areas of life science research.
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