{"title":"天然多糖与减少肠道屏障损伤在心血管疾病。","authors":"Guo-Chen Zhong, Peng Zhou","doi":"10.1007/s11010-025-05352-6","DOIUrl":null,"url":null,"abstract":"<p><p>Natural polysaccharides are a potential therapy for cardiovascular diseases (CVDs) resulting from intestinal barrier injury. More studies on the protective effects of natural polysaccharides on intestinal barrier injury are being conducted, although the underlying mechanisms remain unknown. Thus, the objective of this paper is to discuss current research on natural polysaccharides to reduce the risk of CVDs by preventing intestinal barrier injury. In addition, the protective benefits of natural polysaccharides against CVDs are explored. Finally, the preliminary structure-activity relationship of natural polysaccharides was discussed, which provided the theoretical basis for the modification of lead compound. These natural polysaccharides can enhance the intestinal barrier function of the intestine, hence preventing the incidence and development of CVDs.</p>","PeriodicalId":18724,"journal":{"name":"Molecular and Cellular Biochemistry","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Natural polysaccharides with the reduction of intestinal barrier damage in cardiovascular diseases.\",\"authors\":\"Guo-Chen Zhong, Peng Zhou\",\"doi\":\"10.1007/s11010-025-05352-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Natural polysaccharides are a potential therapy for cardiovascular diseases (CVDs) resulting from intestinal barrier injury. More studies on the protective effects of natural polysaccharides on intestinal barrier injury are being conducted, although the underlying mechanisms remain unknown. Thus, the objective of this paper is to discuss current research on natural polysaccharides to reduce the risk of CVDs by preventing intestinal barrier injury. In addition, the protective benefits of natural polysaccharides against CVDs are explored. Finally, the preliminary structure-activity relationship of natural polysaccharides was discussed, which provided the theoretical basis for the modification of lead compound. These natural polysaccharides can enhance the intestinal barrier function of the intestine, hence preventing the incidence and development of CVDs.</p>\",\"PeriodicalId\":18724,\"journal\":{\"name\":\"Molecular and Cellular Biochemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-07-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular and Cellular Biochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s11010-025-05352-6\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular and Cellular Biochemistry","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s11010-025-05352-6","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Natural polysaccharides with the reduction of intestinal barrier damage in cardiovascular diseases.
Natural polysaccharides are a potential therapy for cardiovascular diseases (CVDs) resulting from intestinal barrier injury. More studies on the protective effects of natural polysaccharides on intestinal barrier injury are being conducted, although the underlying mechanisms remain unknown. Thus, the objective of this paper is to discuss current research on natural polysaccharides to reduce the risk of CVDs by preventing intestinal barrier injury. In addition, the protective benefits of natural polysaccharides against CVDs are explored. Finally, the preliminary structure-activity relationship of natural polysaccharides was discussed, which provided the theoretical basis for the modification of lead compound. These natural polysaccharides can enhance the intestinal barrier function of the intestine, hence preventing the incidence and development of CVDs.
期刊介绍：
Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell.
In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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