{"title":"发现隐藏的环节：缺铜引起的血液病。","authors":"Akiyoshi Takami, Kaori Uchino","doi":"10.1007/s12185-025-04036-7","DOIUrl":null,"url":null,"abstract":"<p><p>Copper deficiency can lead to anemia, leukopenia, or thrombocytopenia, often mimicking vitamin B<sub>12</sub> deficiency or myelodysplastic syndrome. We review the crucial role of copper in iron metabolism and hematopoiesis, highlighting how high-dose zinc supplementation, gastrointestinal surgeries, and long-term nutritional support can induce deficiency. The pathophysiology involves compromised ferroxidase activity, which hampers iron utilization, and reduced neutrophil survival due to impairment of cytochrome c oxidase and superoxide dismutase. Timely recognition is vital, as most cases respond to copper repletion and zinc reduction. Institutional data underscore the need for routine copper monitoring, and management strategies aim to optimize patient care by maintaining adequate copper levels.</p>","PeriodicalId":13992,"journal":{"name":"International Journal of Hematology","volume":" ","pages":"358-367"},"PeriodicalIF":1.8000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Discovering the hidden link: hematological disorders caused by copper deficiency.\",\"authors\":\"Akiyoshi Takami, Kaori Uchino\",\"doi\":\"10.1007/s12185-025-04036-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Copper deficiency can lead to anemia, leukopenia, or thrombocytopenia, often mimicking vitamin B<sub>12</sub> deficiency or myelodysplastic syndrome. We review the crucial role of copper in iron metabolism and hematopoiesis, highlighting how high-dose zinc supplementation, gastrointestinal surgeries, and long-term nutritional support can induce deficiency. The pathophysiology involves compromised ferroxidase activity, which hampers iron utilization, and reduced neutrophil survival due to impairment of cytochrome c oxidase and superoxide dismutase. Timely recognition is vital, as most cases respond to copper repletion and zinc reduction. Institutional data underscore the need for routine copper monitoring, and management strategies aim to optimize patient care by maintaining adequate copper levels.</p>\",\"PeriodicalId\":13992,\"journal\":{\"name\":\"International Journal of Hematology\",\"volume\":\" \",\"pages\":\"358-367\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Hematology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12185-025-04036-7\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Hematology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12185-025-04036-7","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/14 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Discovering the hidden link: hematological disorders caused by copper deficiency.
Copper deficiency can lead to anemia, leukopenia, or thrombocytopenia, often mimicking vitamin B12 deficiency or myelodysplastic syndrome. We review the crucial role of copper in iron metabolism and hematopoiesis, highlighting how high-dose zinc supplementation, gastrointestinal surgeries, and long-term nutritional support can induce deficiency. The pathophysiology involves compromised ferroxidase activity, which hampers iron utilization, and reduced neutrophil survival due to impairment of cytochrome c oxidase and superoxide dismutase. Timely recognition is vital, as most cases respond to copper repletion and zinc reduction. Institutional data underscore the need for routine copper monitoring, and management strategies aim to optimize patient care by maintaining adequate copper levels.
期刊介绍：
The International Journal of Hematology, the official journal of the Japanese Society of Hematology, has a long history of publishing leading research in hematology. The journal comprises articles that contribute to progress in research not only in basic hematology but also in clinical hematology, aiming to cover all aspects of this field, namely, erythrocytes, leukocytes and hematopoiesis, hemostasis, thrombosis and vascular biology, hematological malignancies, transplantation, and cell therapy. The expanded [Progress in Hematology] section integrates such relevant fields as the cell biology of stem cells and cancer cells, and clinical research in inflammation, cancer, and thrombosis. Reports on results of clinical trials are also included, thus contributing to the aim of fostering communication among researchers in the growing field of modern hematology. The journal provides the best of up-to-date information on modern hematology, presenting readers with high-impact, original work focusing on pivotal issues.
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