Role of annexin A7 in the occurrence and progression of coronary atherosclerosis: a narrative review.

Background and objective: Cardiovascular diseases, particularly coronary atherosclerosis, pose a major health burden, with plaque rupture and erosion contributing to acute coronary syndrome (ACS). Platelet adhesion and aggregation are key in thrombosis, making them critical therapeutic targets. This study aimed to elucidate the regulatory role of annexin A7 (ANXA7) in the progression of coronary atherosclerosis.

Methods: A literature review was performed using PubMed and Google Scholar. Clinical trials, meta-analyses, randomized controlled trials, reviews, and systematic reviews were considered. Articles published in languages other than English with limited text availability were excluded.

Key content and findings: ANXA7 plays a crucial role in coronary atherosclerosis by regulating endothelial stability, inflammatory metabolism, and Ca²⁺ mobilization, which influences platelet activation and lipid metabolism. Its potential to prevent thrombosis without impairing hemostasis may offer a breakthrough in platelet therapy for coronary artery disease (CAD).

Conclusions: As a multifunctional regulatory factor, ANXA7 participates in coronary atherosclerosis progression through calcium signaling modulation and inflammatory metabolic regulation, with its unique "antithrombotic without compromising hemostasis" property holding promise to overcome current therapeutic limitations in CAD. Further investigation into the role of ANXA7 in coronary atherosclerosis is crucial for elucidating its pathogenic mechanisms and exploring potential clinical applications.