2型糖尿病患者阿德尔菲依从性问卷（ADAQ©）作为常规护理依从性及影响依从性的复杂因素的新测量方法的心理测量学评价

IF 5.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes, Obesity & Metabolism Pub Date : 2025-07-14 DOI:10.1111/dom.16551

Jan Stochl, Nathan Clarke, Daniel Green, Jonathan Comins, Victoria Higgins, James Piercy, Rob Arbuckle, Tariq Halasa, Thaís Rocha, Kamlesh Khunti

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引用次数: 0

摘要

目的：评价阿德尔菲依从性问卷（ADAQ©）作为常规临床实践中不同类型2型糖尿病（T2DM）人群依从性测量指标的心理测量特性。材料和方法：数据来自Adelphi T2DM疾病特定计划™，该计划是2021年2月至5月期间在美国对患有T2DM的医生和成人进行的一项调查。参与者完成ADAQ和用药满意度、便捷性单项问题。潜在变量模型（探索性/验证性因素分析、项目反应理论、Mokken量表和双因素分析）评估了ADAQ维度和综合评分。差异项目功能（DIF）分析在接受注射和非注射治疗的参与者之间进行，结果：总体而言，1287例T2DM患者被纳入该分析（平均年龄56.7岁[标准差：12.8],54.5% [n = 702]男性）。潜在变量模型表明一维反射模型拟合，双因素模型证实了11个问题本质上是一维复合分数。组间DIF可忽略不计。Cronbach's α和McDonald's ω均≥0.90。与医生报告的依从性和依从性，以及患者报告的用药便利性和满意度支持结构效度有中等相关性。结论：ADAQ在异质性T2DM人群中具有较强的结构效度和较高的内部一致性信度，亚组间的DIF可以忽略不计。未来的工作应侧重于测试-重测可靠性和检测随时间的变化。

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Psychometric evaluation of the Adelphi Adherence Questionnaire (ADAQ©) in a type 2 diabetes mellitus population as a new measure of adherence and the complex factors influencing adherence in routine care.

Aims: To evaluate the psychometric properties of the Adelphi Adherence Questionnaire (ADAQ©) as an adherence measure in a diverse type 2 diabetes mellitus (T2DM) population in routine clinical practice.

Materials and methods: Data were drawn from the Adelphi T2DM Disease Specific Programme™, a survey of physicians and adults with T2DM consulting in the United States, February-May 2021. Participants completed the ADAQ and single questions on medication satisfaction and convenience. Latent variable modelling (exploratory/confirmatory factor analyses, item response theory, Mokken scaling and bifactor analyses) assessed ADAQ dimensionality and composite scoring. Differential item functioning (DIF) analyses were conducted between participants taking injectable and non-injectable therapies, and with <3 or ≥3 long-term conditions. Correlational analyses with physician-reported adherence and compliance, and patient-reported treatment satisfaction, convenience and side-effects assessed construct validity. ADAQ scores by sociodemographic and clinical factors were also described.

Results: Overall, 1287 people with T2DM were included in this analysis (mean age 56.7 years [standard deviation: 12.8], 54.5% [n = 702] male). Latent variable modelling indicated a unidimensional reflective model fit, with a bifactor model confirming an 11-question essentially unidimensional composite score. Negligible DIF was found between groups. Cronbach's alpha and McDonald's omega were both ≥0.90. Moderate correlations with physician-reported adherence and compliance, and patient-reported medication convenience and satisfaction support construct validity.

Conclusions: The ADAQ shows strong construct validity and high internal consistency reliability within a heterogenous T2DM population with negligible DIF between sub-groups. Future work should focus on test-retest reliability and detecting change over time.

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来源期刊

Diabetes, Obesity & Metabolism 医学-内分泌学与代谢

CiteScore

10.90

自引率

6.90%

发文量

319

审稿时长

3-8 weeks

期刊介绍： Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.