Brianne M. Breidenbach, Ira Driscoll, Matthew P. Glittenberg, Adam J. Paulsen, Sara Fernandes-Taylor, Tarun Naren, Grant S. Roberts, Talia L. Brach, Mackenzie M. Jarchow, Leah E. Symanski, Anna Y. Gaul, Sarah R. Lose, Leonardo A. Rivera-Rivera, Sterling C. Johnson, Sanjay Asthana, Bradley T. Christian, Dane B. Cook, Oliver Wieben, Ozioma C. Okonkwo
{"title":"心肺适能改变独立于体力活动的动脉僵硬度和脑血流量之间的关系","authors":"Brianne M. Breidenbach, Ira Driscoll, Matthew P. Glittenberg, Adam J. Paulsen, Sara Fernandes-Taylor, Tarun Naren, Grant S. Roberts, Talia L. Brach, Mackenzie M. Jarchow, Leah E. Symanski, Anna Y. Gaul, Sarah R. Lose, Leonardo A. Rivera-Rivera, Sterling C. Johnson, Sanjay Asthana, Bradley T. Christian, Dane B. Cook, Oliver Wieben, Ozioma C. Okonkwo","doi":"10.1002/trc2.70130","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Central arterial stiffness and cerebral blood flow (CBF) are inversely related. Poor cardiorespiratory fitness (CRF) and low physical activity (PA) are related to both higher arterial stiffness and lower CBF. The present study examined (i) whether CRF or PA moderate the relationship between arterial stiffness and CBF, and (ii) whether the intensity or the type of PA needs to be considered.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>Participants (<i>N</i> = 78, Mean<sub>AGE</sub> = 64.2±6.14, 72% female) from the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center were categorized into low, average, and high fitness groups based on maximal graded exercise treadmill test performance. PA was assessed using the CHAMPS (Community Health Activities Model Program for Seniors) questionnaire. Based on hours/week, participants were classified as meeting the recommended 2.5 h of moderate intensity PA per week (PA Rec Met). Weekly hours of moderate and low intensity PA were calculated as activities of > 3 or < 3 metabolic equivalents, respectively. Activity type was categorized as exercise-, sports/leisure- and work-related. Arterial stiffness was measured as aortic pulse wave velocity (aoPWV) by 2D phase contrast magnetic resonance imaging (MRI). CBF was assessed by 4D flow MRI in the internal carotid arteries (ICAs), cavernous ICAs, middle cerebral arteries (MCAs), and via two composite measures of total and global flow.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>The association between aoPWV and CBF differed by fitness levels, with a negative relationship in the low fitness group and positive relationships in the average and high fitness groups (all <i>P</i>s<0.05). Significant moderating effects on the relationships between aoPWV and CBF were also observed for PA Rec Met (all <i>P</i>s<0.05), moderate intensity (<i>p </i>= 0.05), and exercise-related (all <i>p’</i>s < 0.02) PA.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Average or high fitness, meeting the PA guidelines, and more specifically, moderate intensity and exercise-related PA seem to attenuate the negative relationship between aoPWV on CBF.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Higher cardiorespiratory fitness (CRF) reduces the negative impact of aortic pulse wave velocity (aoPWV) on cerebral blood flow (CBF)</li>\n \n <li>150 min of moderate physical activity (PA) also mitigates this impact, depending on activity type</li>\n \n <li>Innovative methods: use of cardiac magnetic resonance imaging (MRI) for aoPWV assessment</li>\n \n <li>Innovative methods: use of free-breathing acquisition during cardiac MRI</li>\n \n <li>Innovative methods: use of cranial 4D flow MRI for CBF assessment</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":53225,"journal":{"name":"Alzheimer''s and Dementia: Translational Research and Clinical Interventions","volume":"11 3","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/trc2.70130","citationCount":"0","resultStr":"{\"title\":\"Cardiorespiratory fitness modifies the relationship between arterial stiffness and cerebral blood flow independent of physical activity\",\"authors\":\"Brianne M. Breidenbach, Ira Driscoll, Matthew P. Glittenberg, Adam J. Paulsen, Sara Fernandes-Taylor, Tarun Naren, Grant S. Roberts, Talia L. Brach, Mackenzie M. Jarchow, Leah E. Symanski, Anna Y. Gaul, Sarah R. Lose, Leonardo A. Rivera-Rivera, Sterling C. Johnson, Sanjay Asthana, Bradley T. Christian, Dane B. Cook, Oliver Wieben, Ozioma C. Okonkwo\",\"doi\":\"10.1002/trc2.70130\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>Central arterial stiffness and cerebral blood flow (CBF) are inversely related. Poor cardiorespiratory fitness (CRF) and low physical activity (PA) are related to both higher arterial stiffness and lower CBF. The present study examined (i) whether CRF or PA moderate the relationship between arterial stiffness and CBF, and (ii) whether the intensity or the type of PA needs to be considered.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>Participants (<i>N</i> = 78, Mean<sub>AGE</sub> = 64.2±6.14, 72% female) from the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center were categorized into low, average, and high fitness groups based on maximal graded exercise treadmill test performance. PA was assessed using the CHAMPS (Community Health Activities Model Program for Seniors) questionnaire. Based on hours/week, participants were classified as meeting the recommended 2.5 h of moderate intensity PA per week (PA Rec Met). Weekly hours of moderate and low intensity PA were calculated as activities of > 3 or < 3 metabolic equivalents, respectively. Activity type was categorized as exercise-, sports/leisure- and work-related. Arterial stiffness was measured as aortic pulse wave velocity (aoPWV) by 2D phase contrast magnetic resonance imaging (MRI). CBF was assessed by 4D flow MRI in the internal carotid arteries (ICAs), cavernous ICAs, middle cerebral arteries (MCAs), and via two composite measures of total and global flow.</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>The association between aoPWV and CBF differed by fitness levels, with a negative relationship in the low fitness group and positive relationships in the average and high fitness groups (all <i>P</i>s<0.05). Significant moderating effects on the relationships between aoPWV and CBF were also observed for PA Rec Met (all <i>P</i>s<0.05), moderate intensity (<i>p </i>= 0.05), and exercise-related (all <i>p’</i>s < 0.02) PA.</p>\\n </section>\\n \\n <section>\\n \\n <h3> DISCUSSION</h3>\\n \\n <p>Average or high fitness, meeting the PA guidelines, and more specifically, moderate intensity and exercise-related PA seem to attenuate the negative relationship between aoPWV on CBF.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>Higher cardiorespiratory fitness (CRF) reduces the negative impact of aortic pulse wave velocity (aoPWV) on cerebral blood flow (CBF)</li>\\n \\n <li>150 min of moderate physical activity (PA) also mitigates this impact, depending on activity type</li>\\n \\n <li>Innovative methods: use of cardiac magnetic resonance imaging (MRI) for aoPWV assessment</li>\\n \\n <li>Innovative methods: use of free-breathing acquisition during cardiac MRI</li>\\n \\n <li>Innovative methods: use of cranial 4D flow MRI for CBF assessment</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":53225,\"journal\":{\"name\":\"Alzheimer''s and Dementia: Translational Research and Clinical Interventions\",\"volume\":\"11 3\",\"pages\":\"\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/trc2.70130\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer''s and Dementia: Translational Research and Clinical Interventions\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/trc2.70130\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer''s and Dementia: Translational Research and Clinical Interventions","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/trc2.70130","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Cardiorespiratory fitness modifies the relationship between arterial stiffness and cerebral blood flow independent of physical activity
INTRODUCTION
Central arterial stiffness and cerebral blood flow (CBF) are inversely related. Poor cardiorespiratory fitness (CRF) and low physical activity (PA) are related to both higher arterial stiffness and lower CBF. The present study examined (i) whether CRF or PA moderate the relationship between arterial stiffness and CBF, and (ii) whether the intensity or the type of PA needs to be considered.
METHODS
Participants (N = 78, MeanAGE = 64.2±6.14, 72% female) from the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center were categorized into low, average, and high fitness groups based on maximal graded exercise treadmill test performance. PA was assessed using the CHAMPS (Community Health Activities Model Program for Seniors) questionnaire. Based on hours/week, participants were classified as meeting the recommended 2.5 h of moderate intensity PA per week (PA Rec Met). Weekly hours of moderate and low intensity PA were calculated as activities of > 3 or < 3 metabolic equivalents, respectively. Activity type was categorized as exercise-, sports/leisure- and work-related. Arterial stiffness was measured as aortic pulse wave velocity (aoPWV) by 2D phase contrast magnetic resonance imaging (MRI). CBF was assessed by 4D flow MRI in the internal carotid arteries (ICAs), cavernous ICAs, middle cerebral arteries (MCAs), and via two composite measures of total and global flow.
RESULTS
The association between aoPWV and CBF differed by fitness levels, with a negative relationship in the low fitness group and positive relationships in the average and high fitness groups (all Ps<0.05). Significant moderating effects on the relationships between aoPWV and CBF were also observed for PA Rec Met (all Ps<0.05), moderate intensity (p = 0.05), and exercise-related (all p’s < 0.02) PA.
DISCUSSION
Average or high fitness, meeting the PA guidelines, and more specifically, moderate intensity and exercise-related PA seem to attenuate the negative relationship between aoPWV on CBF.
Highlights
Higher cardiorespiratory fitness (CRF) reduces the negative impact of aortic pulse wave velocity (aoPWV) on cerebral blood flow (CBF)
150 min of moderate physical activity (PA) also mitigates this impact, depending on activity type
Innovative methods: use of cardiac magnetic resonance imaging (MRI) for aoPWV assessment
Innovative methods: use of free-breathing acquisition during cardiac MRI
Innovative methods: use of cranial 4D flow MRI for CBF assessment
期刊介绍：
Alzheimer''s & Dementia: Translational Research & Clinical Interventions (TRCI) is a peer-reviewed, open access,journal from the Alzheimer''s Association®. The journal seeks to bridge the full scope of explorations between basic research on drug discovery and clinical studies, validating putative therapies for aging-related chronic brain conditions that affect cognition, motor functions, and other behavioral or clinical symptoms associated with all forms dementia and Alzheimer''s disease. The journal will publish findings from diverse domains of research and disciplines to accelerate the conversion of abstract facts into practical knowledge: specifically, to translate what is learned at the bench into bedside applications. The journal seeks to publish articles that go beyond a singular emphasis on either basic drug discovery research or clinical research. Rather, an important theme of articles will be the linkages between and among the various discrete steps in the complex continuum of therapy development. For rapid communication among a multidisciplinary research audience involving the range of therapeutic interventions, TRCI will consider only original contributions that include feature length research articles, systematic reviews, meta-analyses, brief reports, narrative reviews, commentaries, letters, perspectives, and research news that would advance wide range of interventions to ameliorate symptoms or alter the progression of chronic neurocognitive disorders such as dementia and Alzheimer''s disease. The journal will publish on topics related to medicine, geriatrics, neuroscience, neurophysiology, neurology, psychiatry, clinical psychology, bioinformatics, pharmaco-genetics, regulatory issues, health economics, pharmacoeconomics, and public health policy as these apply to preclinical and clinical research on therapeutics.
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