趋化因子受体-举例说明G蛋白偶联受体的功能分化。

IF 3.2 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Omolade Otun, Sébastien Granier, Thierry Durroux, Cherine Bechara
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引用次数: 0

摘要

众所周知,G蛋白偶联受体能够通过与各种细胞内伴侣的相互作用产生广泛的功能反应。这种多功能性在趋化因子受体家族中尤为明显,其中传统受体主要通过经典的G蛋白偶联途径发出信号,而非典型趋化因子受体似乎不具备这种能力,而是与其他细胞内伙伴(如β-阻滞蛋白)偶联。信号的功能多样性为药物开发提供了独特的机会,允许不同的途径被选择性地靶向以满足特定的治疗需求。这篇综述探讨了G蛋白偶联受体信号的机制,特别是在趋化因子受体家族中,可以在调节、跨膜和细胞内水平上多样化。意义声明:这篇综述探讨了趋化因子受体家族的信号如何在配体、跨膜和细胞内水平上多样化。这种功能多样性通过选择性地靶向不同的途径为药物开发提供了独特的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chemokine receptors - Exemplifying functional divergence in G protein-coupled receptors.

G protein-coupled receptors are known for their ability to generate a wide range of functional responses through interaction with various intracellular partners. This versatility is particularly evident within the chemokine receptor family, where conventional receptors signal primarily through classic G protein-coupled pathways while atypical chemokine receptors appear not to possess such ability but instead couple to alternative intracellular partners such as β-arrestins. Functional diversity in signaling presents unique opportunities for drug development, allowing different pathways to be selectively targeted to meet specific therapeutic needs. This minireview explores the mechanisms by which G protein-coupled receptor signaling, particularly within the chemokine receptor family, can be diversified at the modulatory, transmembrane, and intracellular levels. SIGNIFICANCE STATEMENT: This minireview explores how signaling in the chemokine receptor family diversifies at the ligand, transmembrane, and intracellular levels. This functional diversity presents unique opportunities for drug development by selectively targeting distinct pathways.

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来源期刊
Molecular Pharmacology
Molecular Pharmacology 医学-药学
CiteScore
7.20
自引率
2.80%
发文量
50
审稿时长
3-6 weeks
期刊介绍: Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology and toxicology. Relevant topics include: Molecular Signaling / Mechanism of Drug Action Chemical Biology / Drug Discovery Structure of Drug-Receptor Complex Systems Analysis of Drug Action Drug Transport / Metabolism
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