Md Refat Readul Islam, Rafiqul Islam, Hidehiko Sano, Yu Toida, Shuhei Hoshika, Hany Mohamed Aly Ahmed, Atsushi Tomokiyo
{"title":"可注射水凝胶用于重要牙髓治疗的新趋势：全面回顾。","authors":"Md Refat Readul Islam, Rafiqul Islam, Hidehiko Sano, Yu Toida, Shuhei Hoshika, Hany Mohamed Aly Ahmed, Atsushi Tomokiyo","doi":"10.1111/iej.14279","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Injectable hydrogels are widely used in biomedicine and tissue engineering. Recently, they have been introduced as promising candidates for vital pulp therapy (VPT) owing to their biocompatibility, in situ adaptability, minimal immunogenicity, and ability to modify the cellular activities of dental pulp exposed to caries or accidental injuries. Although injectable hydrogel-based biomaterials facilitate pulp healing and reparative dentine formation, their clinical utility has not been fully explored.</p><p><strong>Objectives: </strong>To facilitate active research, this review highlights the gaps in current research, including the lack of studies on the long-term in vivo effects of injectable hydrogels and comprehensive interactions between injectable hydrogel and the dentine-pulp complex, which impede clinical translation, especially for VPT.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in PubMed and Scopus in April 2024 using relevant keywords related to injectable hydrogels and VPT. Eligible articles published between 2014 and 2024 included in vitro, in vivo, and clinical studies, addressing the biological function, design, or clinical applicability of injectable hydrogels for VPT.</p><p><strong>Results: </strong>This review covers various biomaterial-based injectable hydrogels developed using hyaluronic acid, gelatine methacryloyl, chitosan, collagen, decellularized extracellular matrix, self-assembling peptides, and nanoparticles for VPT, highlighting possibilities for future clinical translation and innovation. Laboratory studies on injectable hydrogels provide not only promising results, including enhanced pulp healing, reduced inflammation, and homogeneous reparative dentine formation, but also key innovations to enhance the functionality, adaptability, and characteristics of novel injectable hydrogels developed for VPT.</p><p><strong>Conclusion: </strong>Hydrogels functionalized with advanced biomaterials and bioengineering approaches can overcome the existing shortcomings, enabling their smooth transition into clinical practice. Nevertheless, further research is required to elucidate their long-term effects and optimal application methods.</p>","PeriodicalId":13724,"journal":{"name":"International endodontic journal","volume":" ","pages":""},"PeriodicalIF":5.4000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Emerging trends of injectable hydrogels for vital pulp therapy: A comprehensive review.\",\"authors\":\"Md Refat Readul Islam, Rafiqul Islam, Hidehiko Sano, Yu Toida, Shuhei Hoshika, Hany Mohamed Aly Ahmed, Atsushi Tomokiyo\",\"doi\":\"10.1111/iej.14279\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Injectable hydrogels are widely used in biomedicine and tissue engineering. Recently, they have been introduced as promising candidates for vital pulp therapy (VPT) owing to their biocompatibility, in situ adaptability, minimal immunogenicity, and ability to modify the cellular activities of dental pulp exposed to caries or accidental injuries. Although injectable hydrogel-based biomaterials facilitate pulp healing and reparative dentine formation, their clinical utility has not been fully explored.</p><p><strong>Objectives: </strong>To facilitate active research, this review highlights the gaps in current research, including the lack of studies on the long-term in vivo effects of injectable hydrogels and comprehensive interactions between injectable hydrogel and the dentine-pulp complex, which impede clinical translation, especially for VPT.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in PubMed and Scopus in April 2024 using relevant keywords related to injectable hydrogels and VPT. Eligible articles published between 2014 and 2024 included in vitro, in vivo, and clinical studies, addressing the biological function, design, or clinical applicability of injectable hydrogels for VPT.</p><p><strong>Results: </strong>This review covers various biomaterial-based injectable hydrogels developed using hyaluronic acid, gelatine methacryloyl, chitosan, collagen, decellularized extracellular matrix, self-assembling peptides, and nanoparticles for VPT, highlighting possibilities for future clinical translation and innovation. Laboratory studies on injectable hydrogels provide not only promising results, including enhanced pulp healing, reduced inflammation, and homogeneous reparative dentine formation, but also key innovations to enhance the functionality, adaptability, and characteristics of novel injectable hydrogels developed for VPT.</p><p><strong>Conclusion: </strong>Hydrogels functionalized with advanced biomaterials and bioengineering approaches can overcome the existing shortcomings, enabling their smooth transition into clinical practice. Nevertheless, further research is required to elucidate their long-term effects and optimal application methods.</p>\",\"PeriodicalId\":13724,\"journal\":{\"name\":\"International endodontic journal\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International endodontic journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/iej.14279\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International endodontic journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/iej.14279","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Emerging trends of injectable hydrogels for vital pulp therapy: A comprehensive review.
Background: Injectable hydrogels are widely used in biomedicine and tissue engineering. Recently, they have been introduced as promising candidates for vital pulp therapy (VPT) owing to their biocompatibility, in situ adaptability, minimal immunogenicity, and ability to modify the cellular activities of dental pulp exposed to caries or accidental injuries. Although injectable hydrogel-based biomaterials facilitate pulp healing and reparative dentine formation, their clinical utility has not been fully explored.
Objectives: To facilitate active research, this review highlights the gaps in current research, including the lack of studies on the long-term in vivo effects of injectable hydrogels and comprehensive interactions between injectable hydrogel and the dentine-pulp complex, which impede clinical translation, especially for VPT.
Methods: A comprehensive literature search was conducted in PubMed and Scopus in April 2024 using relevant keywords related to injectable hydrogels and VPT. Eligible articles published between 2014 and 2024 included in vitro, in vivo, and clinical studies, addressing the biological function, design, or clinical applicability of injectable hydrogels for VPT.
Results: This review covers various biomaterial-based injectable hydrogels developed using hyaluronic acid, gelatine methacryloyl, chitosan, collagen, decellularized extracellular matrix, self-assembling peptides, and nanoparticles for VPT, highlighting possibilities for future clinical translation and innovation. Laboratory studies on injectable hydrogels provide not only promising results, including enhanced pulp healing, reduced inflammation, and homogeneous reparative dentine formation, but also key innovations to enhance the functionality, adaptability, and characteristics of novel injectable hydrogels developed for VPT.
Conclusion: Hydrogels functionalized with advanced biomaterials and bioengineering approaches can overcome the existing shortcomings, enabling their smooth transition into clinical practice. Nevertheless, further research is required to elucidate their long-term effects and optimal application methods.
期刊介绍：
The International Endodontic Journal is published monthly and strives to publish original articles of the highest quality to disseminate scientific and clinical knowledge; all manuscripts are subjected to peer review. Original scientific articles are published in the areas of biomedical science, applied materials science, bioengineering, epidemiology and social science relevant to endodontic disease and its management, and to the restoration of root-treated teeth. In addition, review articles, reports of clinical cases, book reviews, summaries and abstracts of scientific meetings and news items are accepted.
The International Endodontic Journal is essential reading for general dental practitioners, specialist endodontists, research, scientists and dental teachers.
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