Sancho Pedro Xavier, Audêncio Victor, Noemi Dreyer Galvão, Ageo Mario Cândido da Silva
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引用次数: 0
摘要
简介:诺图图被广泛认为是评估癌症预后的有效预测工具,提供个性化和实用的方法来支持临床决策。本研究旨在建立并验证预测宫颈癌住院患者生存的nomogram (nomogram)。方法:从巴西马托格罗索州统一卫生系统(SUS)医院信息系统(SIH)中获取2011 - 2023年的合格数据。基于先前发表的多变量Cox回归模型构建了nomogram。采用Harrell’s concordance index (C-index)和校准曲线对模型性能进行评估。结果:开发的nomogram C-index为0.817,具有较好的判别能力。最重要的预测因素包括所执行的医疗程序类型、ICU入院需求和住院费用。校准曲线显示实际和预测的30天生存概率之间有很好的一致性。结论:开发了一种有用的临床nomogram来计算住院CC患者的生存概率,该模型表现出优异的性能,帮助医疗保健专业人员选择更合适的治疗方法,并为临床和研究背景提供准确的预后预测。
Nomogram predicting overall survival in hospitalized cervical cancer patients in Mato Grosso, Brazil.
Introduction: Nomograms are widely recognized as effective predictive tools for estimating cancer prognosis, providing a personalized and practical approach to support clinical decision-making. This study aimed to develop and validate a nomogram for predicting the survival of hospitalized patients with cervical cancer (CC).
Methods: Eligible data were obtained from the Hospital Information System (SIH) of Brazil's Unified Health System (SUS) in Mato Grosso State, covering the period from 2011 to 2023. A nomogram was constructed based on a previously published multivariable Cox regression model. Model performance was assessed using Harrell's concordance index (C-index) and a calibration curve.
Results: The developed nomogram achieved a C-index of 0.817, indicating good discriminative ability. The most significant predictors included the type of medical procedure performed, the need for ICU admission, and hospital costs. The calibration curve demonstrated good agreement between actual and predicted 30-day survival probabilities.
Conclusion: A useful clinical nomogram was developed to calculate the probability of survival for hospitalized patients with CC. The model demonstrated excellent performance, assisting healthcare professionals in selecting more appropriate treatments and providing accurate prognostic predictions for both clinical and research contexts.