肥胖孕妇妊娠18-20周的胰岛素水平与新生儿腹部脂肪沉积和脐带血DNA甲基化有关。

IF 4.4 2区医学 Q1 GENETICS & HEREDITY

Clinical Epigenetics Pub Date : 2025-07-11 DOI:10.1186/s13148-025-01923-y

Alice Maguolo, Josefine Jönsson, Alexander Perfilyev, Allan Vaag, Emma Malchau Carlsen, Kirsten Nørgaard, Paul W Franks, Kristina M Renault, Charlotte Ling

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引用次数: 0

摘要

我们评估了肥胖孕妇的空腹血浆胰岛素水平是否与新生儿腹部脂肪沉积（双能x线吸收仪）和脐带血DNA甲基化（450k阵列）有关，研究对象是来自肥胖孕妇治疗（TOP）研究的232对母子。18-20gw空腹孕妇胰岛素与新生儿腹部/总脂肪质量比相关，独立于多个潜在混杂因素(β = 0.23[95%CI: 0.01；0.45], P = 0.041)，并且在C11orf54和RARB （FDR）注释的CpG位点上存在脐带血DNA甲基化

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Insulin levels at 18-20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood.

We assessed if fasting plasma insulin levels in pregnant women with obesity are associated with newborns' abdominal fat deposition (dual-energy X-ray absorptiometry) and with cord blood DNA methylation (450k array) in 232 mother-child pairs from the Treatment of Obese Pregnant women (TOP) study. Fasting maternal insulin at 18-20gw was associated with abdominal/total fat mass ratio in newborns independent of multiple potential confounders (β = 0.23[95%CI: 0.01; 0.45], P = 0.041) and with cord blood DNA methylation at CpG sites annotated to C11orf54 and RARB (FDR < 10%), both genes potentially involved in metabolic programming. In conclusion, maternal insulin levels in pregnancy were associated with adiposity traits and epigenetics in the offspring.

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来源期刊

Clinical Epigenetics ONCOLOGY-

自引率

5.30%

发文量

150

期刊介绍： Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.