{"title":"当星星失火:星形细胞功能障碍在重度抑郁症。","authors":"Candela González-Arias, Gertrudis Perea","doi":"10.1007/s11064-025-04483-y","DOIUrl":null,"url":null,"abstract":"<div><p>Major depressive disorder (MDD) is a global public health concern and the leading cause of disability worldwide. It severely impairs cognitive, emotional, and social functioning, and is associated with attention, memory, and executive function deficits. MDD was traditionally considered as a neuropsychiatric disorder focused on neuronal dysfunction; however, growing evidence recognizes glial cells, particularly astrocytes, as crucial cells for the pathophysiology and pathogenesis of MDD. Astrocytes play essential roles in the central nervous system, including neurotransmitter uptake, metabolic support, neurotrophic factor production, and synaptic regulation. Evidence from MDD human patients, as well as studies involving animal models have revealed the astrocytic dysfunction as a critical factor in the pathophysiology of MDD, pointing to widespread alterations in astrocyte density, morphology, and function. This review summarizes current knowledge regarding astrocytes and MDD and discuss the potential of targeting astrocytes as a novel avenue for antidepressant development.</p></div>","PeriodicalId":719,"journal":{"name":"Neurochemical Research","volume":"50 4","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255599/pdf/","citationCount":"0","resultStr":"{\"title\":\"When the Stars Misfire: Astrocytic Dysfunctions in Major Depressive Disorder\",\"authors\":\"Candela González-Arias, Gertrudis Perea\",\"doi\":\"10.1007/s11064-025-04483-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Major depressive disorder (MDD) is a global public health concern and the leading cause of disability worldwide. It severely impairs cognitive, emotional, and social functioning, and is associated with attention, memory, and executive function deficits. MDD was traditionally considered as a neuropsychiatric disorder focused on neuronal dysfunction; however, growing evidence recognizes glial cells, particularly astrocytes, as crucial cells for the pathophysiology and pathogenesis of MDD. Astrocytes play essential roles in the central nervous system, including neurotransmitter uptake, metabolic support, neurotrophic factor production, and synaptic regulation. Evidence from MDD human patients, as well as studies involving animal models have revealed the astrocytic dysfunction as a critical factor in the pathophysiology of MDD, pointing to widespread alterations in astrocyte density, morphology, and function. This review summarizes current knowledge regarding astrocytes and MDD and discuss the potential of targeting astrocytes as a novel avenue for antidepressant development.</p></div>\",\"PeriodicalId\":719,\"journal\":{\"name\":\"Neurochemical Research\",\"volume\":\"50 4\",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255599/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurochemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11064-025-04483-y\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemical Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s11064-025-04483-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
When the Stars Misfire: Astrocytic Dysfunctions in Major Depressive Disorder
Major depressive disorder (MDD) is a global public health concern and the leading cause of disability worldwide. It severely impairs cognitive, emotional, and social functioning, and is associated with attention, memory, and executive function deficits. MDD was traditionally considered as a neuropsychiatric disorder focused on neuronal dysfunction; however, growing evidence recognizes glial cells, particularly astrocytes, as crucial cells for the pathophysiology and pathogenesis of MDD. Astrocytes play essential roles in the central nervous system, including neurotransmitter uptake, metabolic support, neurotrophic factor production, and synaptic regulation. Evidence from MDD human patients, as well as studies involving animal models have revealed the astrocytic dysfunction as a critical factor in the pathophysiology of MDD, pointing to widespread alterations in astrocyte density, morphology, and function. This review summarizes current knowledge regarding astrocytes and MDD and discuss the potential of targeting astrocytes as a novel avenue for antidepressant development.
期刊介绍:
Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.