Anjaneyulu Bendi, Anirudh Singh Bhathiwal, Aditi Tiwari, G. B. Dharma Rao, Mozhgan Afshari
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Microwave-Assisted One-Pot Synthesis of 1,5-Benzodiazepine Derivatives Using Novel ZnFe2O4.Cu(OH)2 Magnetic Nanocomposite as Heterogeneous Catalyst and Their Theoretical Studies as Antifungal Agents
Incredible applications of 1,5-benzodiazepine derivatives in the pharmacological and biological world have encouraged us to synthesize the series of novel 2,4-disubstituted-1,5-benzodiazepine derivatives in one pot using reusable ZnFe2O4.Cu(OH)2 magnetic nanocomposite as a heterogeneous catalyst under microwave irradiation with a yield range of 70%–93%. The novel ZnFe2O4.Cu(OH)2 catalyst was characterized by XRD and TEM. The synthesized 1,5-benzodiazepine derivatives are further investigated for theoretical DFT observations using Spartan-14 software, Autodock Vina, and Discovery Studio software to study their antifungal activity effectiveness towards CaCYP51 (PDB ID-5EQB) protein and observed that almost all compounds exhibit antifungal activity.
期刊介绍：
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.
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