A New Route for the Synthesis of Thiazole-Fused Pyrimidinone Derivatives via Regioselective Intramolecular Mitsunobu Reaction

This study presents a new route for synthesizing thiazole-fused pyrimidinone derivatives through a regioselective intramolecular Mitsunobu reaction. Previous methods used simultaneous bis-alkylation or 2-aminothiazoline as the uronium derivative in ring closure to form the desired products. However, these methodologies can give a mixture of regioisomers, which was not observed in our results. The developed method showed good to moderate chemical yields and can be applied to synthesizing biologically active compounds.