肿瘤内钙稳态及进展转移机制研究

IF 9.1 1区医学 Q1 ONCOLOGY

Cancer letters Pub Date : 2025-07-11 DOI:10.1016/j.canlet.2025.217908

Zhenpu Qin , Yuqin Di , Tianrong Ma , Wei Zeng , Xianzhi Liu , Weiling He

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引用次数: 0

摘要

钙离子（Ca2+）是细胞内重要的第二信使，在细胞生理功能和信号转导中起着关键作用。Ca2+通过调节细胞骨架重组、细胞迁移、侵袭和免疫逃逸等机制，显著影响肿瘤细胞的生物学行为。虽然钙稳态在肿瘤进展和转移中的研究历来有限，但近年来已受到广泛关注。越来越多的证据表明，钙稳态的破坏与肿瘤的发生、侵袭和转移密切相关。本文系统地综述了肿瘤进展和转移过程中钙稳态的调控机制。我们关注钙通道、钙泵及其在离子信号网络、肿瘤微环境、下游信号通路和免疫逃逸中的调节作用。我们还讨论了通过调节钙稳态靶向肿瘤进展和转移的治疗策略。本文旨在通过阐明钙稳态在肿瘤转移中的作用，为新的抗转移策略提供理论基础和潜在靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The calcium homeostasis in tumor and the mechanism involving progression and metastasis

Calcium ions (Ca²⁺) act as important intracellular second messengers and play a key role in cellular physiological functions and signal transduction. Ca²⁺ significantly affects the biological behavior of tumor cells by regulating mechanisms, such as cytoskeleton reorganization, cell migration, invasion, and immune escape. Although research on calcium homeostasis in tumor progression and metastasis was historically limited, it has recently received widespread attention. Growing evidence indicates that the disruption of calcium homeostasis is closely linked to the development, invasion, and metastasis of tumors. This paper systematically reviews the mechanisms governing calcium homeostasis in tumor progression and metastasis. We focused on calcium channels, pumps, and their regulatory roles in ionic signaling networks, the tumor microenvironment, downstream signaling pathways, and immune escape. We also discussed therapeutic strategies targeting tumor progression and metastasis via the modulation of calcium homeostasis. By elucidating the role of calcium homeostasis in tumor metastasis, this review aims to provide a theoretical foundation and to identify potential targets for novel anti-metastatic strategies.

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来源期刊

Cancer letters 医学-肿瘤学

CiteScore

17.70

自引率

2.10%

发文量

427

审稿时长

15 days

期刊介绍： Cancer Letters is a reputable international journal that serves as a platform for significant and original contributions in cancer research. The journal welcomes both full-length articles and Mini Reviews in the wide-ranging field of basic and translational oncology. Furthermore, it frequently presents Special Issues that shed light on current and topical areas in cancer research. Cancer Letters is highly interested in various fundamental aspects that can cater to a diverse readership. These areas include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal actively focuses on experimental therapeutics, particularly the advancement of targeted therapies for personalized cancer medicine, such as metronomic chemotherapy. By publishing groundbreaking research and promoting advancements in cancer treatments, Cancer Letters aims to actively contribute to the fight against cancer and the improvement of patient outcomes.