Jacinta N Omeke, Ifeanyi Onyema, Harriet N Ikenna-Eze, Iniobong C Ugochukwu, Didacus C Eze, Wilfred S Ezema, John O A Okoye
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引用次数: 0
摘要
本研究评估了多次La Sota疫苗接种对与新城疫病毒(vNDV)感染相关的小母鸡淋巴器官萎缩的影响。将200只雏鸡随机分为5组,分别为未接种疫苗未攻毒{UU}、未接种疫苗攻毒{UC}、La Sota 1 {L1}、La Sota 2 {L2}和La Sota 3 {L3}。在3周龄时,L1、L2和L3组雏鸡接种La Sota疫苗。在5周时,L2组和L3组接受第二剂疫苗。7周时,只有L3组接受第三次剂量。在10周时,接种疫苗组和UC组的禽类肌肉注射0.1 ml vNDV Kudu 113。在攻毒(PC)后第2天和第3天观察到UC的ND临床症状和死亡率,而接种组未观察到死亡率。免疫组淋巴器官萎缩在第3天和第7天更严重。在第7、14和21天,L1和L2的抗体滴度高于L3。本研究表明,连续接种3次以上的La Sota疫苗可导致淋巴器官严重萎缩。
Effects of multiple La Sota vaccinations on the atrophy of the lymphoid organs associated with velogenic Newcastle disease virus infection in pullets.
This research evaluated the effects of multiple La Sota vaccinations on atrophy of the lymphoid organs associated with the velogenic Newcastle disease virus (vNDV) infection in pullets. Two hundred pullets were randomly assigned into five groups designated as unvaccinated unchallenged {UU}, unvaccinated challenged {UC}, La Sota 1 {L1}, La Sota 2 {L2} and La Sota 3 {L3}. At three weeks old, pullets in groups L1, L2 and L3 were vaccinated with La Sota vaccine. At five weeks, L2 and L3 groups received a second dose of the vaccine. At 7 weeks, only L3 group received the third dose. At ten weeks, birds in vaccinated and UC groups were challenged with 0.1 ml of vNDV Kudu 113 intramuscularly. Clinical signs of ND and mortality were observed in UC on days 2 and 3 post challenged (PC) while no mortality was observed in vaccinated groups. Atrophy of the lymphoid organs observed in vaccinated groups was more severe in L3 on days 3 and 7 PC. On days 7, 14 and 21 PC, antibody titre was higher in L1 and L2 than in L3. This study showed that multiple La Sota vaccinations up to 3 successive times cause severe atrophy of the lymphoid organs.
期刊介绍:
Acta Veterinaria Hungarica publishes original research papers presenting new scientific results of international interest, and to a limited extent also review articles and clinical case reports, on veterinary physiology (physiological chemistry and metabolism), veterinary microbiology (bacteriology, virology, immunology, molecular biology), on the infectious diseases of domestic animals, on veterinary parasitology, pathology, clinical veterinary science and reproduction.