Mevlüt Doğukan, Nezir Yılmaz, Ahmet Türk, Fadime Tosun, Mehmet Duran, Zeliha Bozkurt
{"title":"静脉注射脂质乳对布比卡因心脏毒性后的神经保护作用。","authors":"Mevlüt Doğukan, Nezir Yılmaz, Ahmet Türk, Fadime Tosun, Mehmet Duran, Zeliha Bozkurt","doi":"10.4103/sja.sja_810_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the protective effects of intravenous lipid emulsion (ILE) against bupivacaine-induced cardiac toxicity, using histopathological analyses.</p><p><strong>Methods: </strong>Twenty-eight adult male Wistar-Albino rats were divided into four groups: Sham (Group A), ILE (Group B), Bupivacaine (Group C), and Bupivacaine + ILE (Group D). Neurotoxicity was induced in Groups C and D with continuous bupivacaine infusion. ILE was administered to Groups B and D. Histological examination of brain tissues, and apoptotic index were evaluated.</p><p><strong>Results: </strong>The apoptotic index was significantly higher in Group C, but ILE administration in Group D markedly decreased these parameters (<i>P</i> < 0.05). Histopathological analysis revealed that ILE reduced edema and neuronal degeneration in Group D.</p><p><strong>Conclusion: </strong>ILE demonstrated a neuroprotective effect against bupivacaine-induced cardiac toxicity by improving hemodynamic stability and reducing cellular damage. This suggests a potential therapeutic role of ILE in managing local anesthetic systemic toxicity.</p>","PeriodicalId":21533,"journal":{"name":"Saudi Journal of Anaesthesia","volume":"19 3","pages":"363-367"},"PeriodicalIF":1.3000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240504/pdf/","citationCount":"0","resultStr":"{\"title\":\"Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicity.\",\"authors\":\"Mevlüt Doğukan, Nezir Yılmaz, Ahmet Türk, Fadime Tosun, Mehmet Duran, Zeliha Bozkurt\",\"doi\":\"10.4103/sja.sja_810_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This study aimed to investigate the protective effects of intravenous lipid emulsion (ILE) against bupivacaine-induced cardiac toxicity, using histopathological analyses.</p><p><strong>Methods: </strong>Twenty-eight adult male Wistar-Albino rats were divided into four groups: Sham (Group A), ILE (Group B), Bupivacaine (Group C), and Bupivacaine + ILE (Group D). Neurotoxicity was induced in Groups C and D with continuous bupivacaine infusion. ILE was administered to Groups B and D. Histological examination of brain tissues, and apoptotic index were evaluated.</p><p><strong>Results: </strong>The apoptotic index was significantly higher in Group C, but ILE administration in Group D markedly decreased these parameters (<i>P</i> < 0.05). Histopathological analysis revealed that ILE reduced edema and neuronal degeneration in Group D.</p><p><strong>Conclusion: </strong>ILE demonstrated a neuroprotective effect against bupivacaine-induced cardiac toxicity by improving hemodynamic stability and reducing cellular damage. This suggests a potential therapeutic role of ILE in managing local anesthetic systemic toxicity.</p>\",\"PeriodicalId\":21533,\"journal\":{\"name\":\"Saudi Journal of Anaesthesia\",\"volume\":\"19 3\",\"pages\":\"363-367\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240504/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Saudi Journal of Anaesthesia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/sja.sja_810_24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/16 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ANESTHESIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Saudi Journal of Anaesthesia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/sja.sja_810_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/16 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicity.
Background: This study aimed to investigate the protective effects of intravenous lipid emulsion (ILE) against bupivacaine-induced cardiac toxicity, using histopathological analyses.
Methods: Twenty-eight adult male Wistar-Albino rats were divided into four groups: Sham (Group A), ILE (Group B), Bupivacaine (Group C), and Bupivacaine + ILE (Group D). Neurotoxicity was induced in Groups C and D with continuous bupivacaine infusion. ILE was administered to Groups B and D. Histological examination of brain tissues, and apoptotic index were evaluated.
Results: The apoptotic index was significantly higher in Group C, but ILE administration in Group D markedly decreased these parameters (P < 0.05). Histopathological analysis revealed that ILE reduced edema and neuronal degeneration in Group D.
Conclusion: ILE demonstrated a neuroprotective effect against bupivacaine-induced cardiac toxicity by improving hemodynamic stability and reducing cellular damage. This suggests a potential therapeutic role of ILE in managing local anesthetic systemic toxicity.
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