肾上腺素激增:在活体供肝移植过程中,毫无疑义的配药错误导致危及生命的错误输注。

IF 1.3 Q3 ANESTHESIOLOGY
Saudi Journal of Anaesthesia Pub Date : 2025-07-01 Epub Date: 2025-06-16 DOI:10.4103/sja.sja_602_24
Amer Majeed, Yazan Chaiah, Abdelrahman Hammad, Salma Alkhani, Mohammed Abduhu Amer, Dieter Clemens Broering
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引用次数: 0

摘要

用药错误有可能对病人造成严重伤害甚至死亡。处方和药物管理错误很常见,而由于难以发现和漏报,配药错误的发生率不太一致。本病例报告描述了一个事件,其中一个繁忙的药房在第四护理医院配发的去甲肾上腺素输液,实际上含有肾上腺素。只有在患者接受活体肝移植手术后,出现了意想不到的、戏剧性的、可能致命的不稳定,并随着去甲肾上腺素剂量的逐渐增加而恶化,这个错误才变得明显。呈现的差异依次被排除,导致意识到所配药的内容可能是不准确的。当新鲜制备的去甲肾上腺素输注取代药房供应的袋子时,不良参数逆转,患者稳定下来。这个案例强调了对药物分配错误保持高度怀疑的重要性,因为这样做有助于确定原因并最终挽救患者的生命。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adrenaline rush: Unsuspicious dispensing error causing life threatening wrong drug infusion during living donor liver transplantation.

Medication errors carry the potential for serious patient harm and even death. Prescription and medication administration errors are common, while the incidence of dispensing errors is less consistent due to difficulties in detection and under-reporting. This case report describes an incident in which a busy pharmacy in a quaternary care hospital dispensed a norepinephrine infusion that actually contained epinephrine. The error became apparent only after the patient, undergoing living donor liver transplantation surgery, developed unexpected, dramatic, and potentially fatal instability, which worsened with progressively higher doses of norepinephrine. The differentials of the presentation were sequentially excluded, leading to the realisation that the contents of the dispensed medicine might have been inaccurate. When a freshly prepared infusion of norepinephrine replaced the pharmacy-supplied bag, the adverse parameters reversed, and the patient stabilised. This case underscores the importance of maintaining a high index of suspicion for medication dispensing errors, as doing so helped identify the cause and ultimately saved the patient's life.

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来源期刊
CiteScore
1.90
自引率
8.30%
发文量
141
审稿时长
36 weeks
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