Francois H Cornelis, Rozan Bokhari, Ruben Geevarghese, Dimitrios K Filippiadis
{"title":"冷冻神经溶解：在PubMed出版物和谷歌趋势分析中平行增长揭示了指数兴趣。","authors":"Francois H Cornelis, Rozan Bokhari, Ruben Geevarghese, Dimitrios K Filippiadis","doi":"10.1007/s00270-025-04118-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study analyzed global interest in cryoneurolysis, a minimally invasive nerve ablation technique for non-opioid pain management, identifying temporal trends, geographic distribution, and commercial drivers influencing adoption.</p><p><strong>Materials and methods: </strong>Retrospective analysis of Google Trends data (January 2004-March 2025) and PubMed publications (1993-2025) using the keyword \"cryoneurolysis.\" Statistical analyses included Mann-Kendall trend tests, Portmanteau white noise tests, Dickey-Fuller unit root tests, and Spearman correlations. Forecasting employed nonseasonal Holt-Winters smoothing and local polynomial regression.</p><p><strong>Results: </strong>Search interest remained negligible (SVI = 0) from 2004 to mid-2019, with academic activity preceding public interest by 3-4 years. Both datasets demonstrated significant upward trends (PubMed: τ = 0.80, p < 0.0001; Google Trends: τ = 0.75, p < 0.0001). Commercial driver \"Iovera\" showed perfect correlation (r = 1.0) with search volume. Geographic concentration was limited to six high-income countries. Forecasting projects sustained growth through 2030, with publications increasing from 46.1 (95% CI: 41.8-50.4) in 2025 to 72.6 (95% CI: 59.2-86.0) by 2030.</p><p><strong>Conclusion: </strong>Analysis reveals parallel academic-public interest growth driven by commercial factors, geographic concentration in developed nations, and emerging applications in interventional radiology, suggesting wider adoption by 2030.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cryoneurolysis: Parallel Growth in PubMed Publications and Google Trends Analysis Reveals Exponential Interest.\",\"authors\":\"Francois H Cornelis, Rozan Bokhari, Ruben Geevarghese, Dimitrios K Filippiadis\",\"doi\":\"10.1007/s00270-025-04118-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study analyzed global interest in cryoneurolysis, a minimally invasive nerve ablation technique for non-opioid pain management, identifying temporal trends, geographic distribution, and commercial drivers influencing adoption.</p><p><strong>Materials and methods: </strong>Retrospective analysis of Google Trends data (January 2004-March 2025) and PubMed publications (1993-2025) using the keyword \\\"cryoneurolysis.\\\" Statistical analyses included Mann-Kendall trend tests, Portmanteau white noise tests, Dickey-Fuller unit root tests, and Spearman correlations. Forecasting employed nonseasonal Holt-Winters smoothing and local polynomial regression.</p><p><strong>Results: </strong>Search interest remained negligible (SVI = 0) from 2004 to mid-2019, with academic activity preceding public interest by 3-4 years. Both datasets demonstrated significant upward trends (PubMed: τ = 0.80, p < 0.0001; Google Trends: τ = 0.75, p < 0.0001). Commercial driver \\\"Iovera\\\" showed perfect correlation (r = 1.0) with search volume. Geographic concentration was limited to six high-income countries. Forecasting projects sustained growth through 2030, with publications increasing from 46.1 (95% CI: 41.8-50.4) in 2025 to 72.6 (95% CI: 59.2-86.0) by 2030.</p><p><strong>Conclusion: </strong>Analysis reveals parallel academic-public interest growth driven by commercial factors, geographic concentration in developed nations, and emerging applications in interventional radiology, suggesting wider adoption by 2030.</p>\",\"PeriodicalId\":9591,\"journal\":{\"name\":\"CardioVascular and Interventional Radiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"CardioVascular and Interventional Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00270-025-04118-3\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"CardioVascular and Interventional Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00270-025-04118-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Cryoneurolysis: Parallel Growth in PubMed Publications and Google Trends Analysis Reveals Exponential Interest.
Purpose: This study analyzed global interest in cryoneurolysis, a minimally invasive nerve ablation technique for non-opioid pain management, identifying temporal trends, geographic distribution, and commercial drivers influencing adoption.
Materials and methods: Retrospective analysis of Google Trends data (January 2004-March 2025) and PubMed publications (1993-2025) using the keyword "cryoneurolysis." Statistical analyses included Mann-Kendall trend tests, Portmanteau white noise tests, Dickey-Fuller unit root tests, and Spearman correlations. Forecasting employed nonseasonal Holt-Winters smoothing and local polynomial regression.
Results: Search interest remained negligible (SVI = 0) from 2004 to mid-2019, with academic activity preceding public interest by 3-4 years. Both datasets demonstrated significant upward trends (PubMed: τ = 0.80, p < 0.0001; Google Trends: τ = 0.75, p < 0.0001). Commercial driver "Iovera" showed perfect correlation (r = 1.0) with search volume. Geographic concentration was limited to six high-income countries. Forecasting projects sustained growth through 2030, with publications increasing from 46.1 (95% CI: 41.8-50.4) in 2025 to 72.6 (95% CI: 59.2-86.0) by 2030.
Conclusion: Analysis reveals parallel academic-public interest growth driven by commercial factors, geographic concentration in developed nations, and emerging applications in interventional radiology, suggesting wider adoption by 2030.
期刊介绍：
CardioVascular and Interventional Radiology (CVIR) is the official journal of the Cardiovascular and Interventional Radiological Society of Europe, and is also the official organ of a number of additional distinguished national and international interventional radiological societies. CVIR publishes double blinded peer-reviewed original research work including clinical and laboratory investigations, technical notes, case reports, works in progress, and letters to the editor, as well as review articles, pictorial essays, editorials, and special invited submissions in the field of vascular and interventional radiology. Beside the communication of the latest research results in this field, it is also the aim of CVIR to support continuous medical education. Articles that are accepted for publication are done so with the understanding that they, or their substantive contents, have not been and will not be submitted to any other publication.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
