白蛋白与纤维蛋白原比值、纤维蛋白原与白蛋白评分在肺癌患者中的预后价值:一项荟萃分析。

IF 1.6 4区 医学 Q3 SURGERY
Zongyuan Li, Yueli Shu, Wenying Xu, Jian Zhang
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引用次数: 0

摘要

背景:我们旨在全面评估肺癌(LC)患者AFR和FA评分的预后表现。方法:综合检索PubMed、Web of Science和CNKI数据库,确定相关研究。评估的主要终点是总生存期(OS)和无进展生存期(PFS)。通过池化分析计算综合风险比(hr)和95%置信区间(ci)。结果:来自10项研究的3145名参与者被纳入分析。在LC患者中,汇总结果显示,低AFR预测较差的OS预后(HR 1.76, 95% CI 1.51-2.06, p)。结论:该荟萃分析表明,低AFR和高FA评分与LC患者死亡和疾病进展风险增加相关,提示它们具有作为预后生物标志物的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Prognostic Value of Albumin-To-Fibrinogen Ratio and Fibrinogen and Albumin Score in Lung Cancer Patients: A Meta-Analysis

Prognostic Value of Albumin-To-Fibrinogen Ratio and Fibrinogen and Albumin Score in Lung Cancer Patients: A Meta-Analysis

Background

We aim to comprehensively assess the prognostic performance of AFR and FA scores in patients with lung cancer (LC).

Methods

We conducted a comprehensive search of PubMed, Web of Science, and CNKI databases to identify relevant studies. The primary endpoints assessed were overall survival (OS) and progression-free survival (PFS). Integrated hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated through pooling analysis.

Results

A total of 3145 participants from 10 studies were included in the analysis. In LC patients, the pooled results showed that low AFR predicted a worse outcome for OS (HR 1.76, 95% CI 1.51–2.06, p < 0.001) and PFS (HR 1.50, 95% CI 1.29–1.74, p < 0.001), and high FA score was associated with worse OS (HR 2.61, 95% CI 1.75–3.90, p < 0.001) and PFS (HR 2.38, 95% CI 1.60–3.55, p < 0.001).

Conclusion

This meta-analysis demonstrated that a low AFR and a high FA score were associated with an increased risk of mortality and disease progression in LC, suggesting their potential as prognostic biomarkers.

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来源期刊
ANZ Journal of Surgery
ANZ Journal of Surgery 医学-外科
CiteScore
2.50
自引率
11.80%
发文量
720
审稿时长
2 months
期刊介绍: ANZ Journal of Surgery is published by Wiley on behalf of the Royal Australasian College of Surgeons to provide a medium for the publication of peer-reviewed original contributions related to clinical practice and/or research in all fields of surgery and related disciplines. It also provides a programme of continuing education for surgeons. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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