Ir(III)-光催化立体选择性合成2-氮二烯。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-10 DOI:10.1021/acs.orglett.5c02366

Biprajit Paul, Sayan Samanta, Surajit Das and Indranil Chatterjee*,

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引用次数: 0

摘要

在温和的反应条件下，建立了光催化、立体选择性的C-N键形成反应，合成了含三氟甲基的2-氮二烯支架。目前的方法采用多任务光催化的面- ir (ppy)3通过能量转移（EnT）机制从稳定的肟-酯前体生成亚胺基自由基。这种亚胺基自由基作为n -关键键被安装在烯烃体系中，通过光氧化还原循环没有任何预官能化。该反应具有好氧条件温和、反应范围广、产率高、立体选择性好等优点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ir(III)-Photocatalyzed Stereoselective Synthesis of 2-Azadienes

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Ir(III)-Photocatalyzed Stereoselective Synthesis of 2-Azadienes

A photocatalyzed, stereoselective C–N bond formation reaction was developed to synthesize 2-azadiene scaffolds containing trifluoromethyl groups under mild reaction conditions. This current methodology employs the multitasking photocatalysis of fac-Ir(ppy)₃ to generate iminyl radicals from bench-stable oxime-ester precursors via an energy transfer (EnT) mechanism. This iminyl radical is installed in the olefinic system as an N-linchpin without any prefunctionalization through a photoredox cycle. The advantages of the reaction consist of mild aerobic reaction conditions, broad scopes, high yield, and impressive stereoselectivity.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.