亚抗菌剂量强力霉素治疗肘关节肌腱病变的可行性

Q2 Medicine
Brett G. Toresdahl MD , Joshua Dines MD , Harry G. Greditzer IV MD , Andy O. Miller MD , Miguel Otero PhD , Jamie S. Egbert MPH , Brianna Quijano MS , Scott Rodeo MD
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引用次数: 0

摘要

背景:弓腱病是运动员和普通人群的常见疾病,可导致严重的残疾和工作时间损失。尽管有传统的治疗方法,但症状通常会持续6个月以上。强力霉素作为基质金属蛋白酶抑制剂已被认为具有治疗肌腱病的潜力。本研究的目的是评估亚抗菌剂量(SD)强力霉素作为一种低成本的辅助治疗方法在肘关节肌腱病变非手术治疗中的可行性。方法除标准护理外,受试者接受强力环素20mg,每天两次,持续12周,包括家庭锻炼计划和反力支架。每周报告任何潜在的副作用,并在12周时计算剩余药片的数量。在基线、4周、8周和12周收集患者报告的结果测量。在基线和12周时评估超声、握力和实验室值。结果本组21例患者,平均年龄50.9岁,男性占57.1%。基线时肘部疼痛的中位周数为14周(四分位数范围为15周)。SD强力霉素没有引起明显的副作用或实验室值的变化。按药片数计算,药物依从性中位数为96%。在随访的多个时间点记录患者报告的结果测量和握力。结论肘关节病变患者对SD强力霉素耐受性较好,大多数患者均符合每日两次的治疗方案,疗程为12周。我们的队列表现出症状和握力的改善。需要进一步的研究来确定SD强力霉素是否有助于这种改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Feasibility of subantimicrobial-dose doxycycline for elbow tendinopathy

Background

Elbow tendinopathy is a common condition among athletes and the general population and can result in significant disability and time loss from work. Despite traditional treatments, symptoms often persist for more than 6 months. Doxycycline has been suggested as having treatment potential for tendinopathy as a matrix metalloproteinase inhibitor. The objective of this study was to evaluate the feasibility of subantimicrobial dose (SD) doxycycline as a low-cost adjunctive treatment in the nonsurgical management of elbow tendinopathy.

Methods

Subjects received doxycycline 20 mg twice per day for 12 weeks in addition to standard of care, including a home exercise program and a counterforce brace. Any potential side effects were reported weekly, and the remaining pills were counted at 12 weeks. Patient-reported outcome measures were collected at baseline, 4, 8, and 12 weeks. Ultrasound, grip strength, and laboratory values were assessed at baseline and 12 weeks.

Results

Our sample consisted of 21 patients (average age 50.9 years, 57.1% male). The median weeks of elbow pain at baseline was 14 (interquartile range 15). SD doxycycline resulted in no significant side effects or changes to laboratory values. Median medication compliance was 96% by pill count. Patient-reported outcome measures and grip strength were recorded at multiple time points in the follow-up.

Conclusion

Patients with elbow tendinopathy tolerated SD doxycycline well and the majority were compliant with a twice-daily regimen for 12 weeks. Our cohort demonstrated improvements in symptoms and grip strength. Further research is needed to determine if SD doxycycline contributes to this improvement.
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来源期刊
JSES International
JSES International Medicine-Surgery
CiteScore
2.80
自引率
0.00%
发文量
174
审稿时长
14 weeks
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