首次进行了超高剂量率氧离子放射治疗的体外和体内实验

IF 3.4 Q2 ONCOLOGY

Physics and Imaging in Radiation Oncology Pub Date : 2025-07-01 DOI:10.1016/j.phro.2025.100803

Celine Karle , Domenico I. Filosa , Mahdi Akbarpour , Nora Schuhmacher , Stephan Brons , Rainer Cee , Christian Schömers , Stefan Scheloske , Kristoffer Petersson , Thomas Haberer , Amir Abdollahi , Jürgen Debus , Thomas Tessonnier , Mahmoud Moustafa , Andrea Mairani , Ivana Dokic

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引用次数: 0

摘要

在这项研究中，我们证明了在三种不同的生物复杂性水平下超高剂量率（UHDR）氧离子照射的可行性。在富含蛋白质的盐水溶液中，UHDR和标准剂量率（SDR）之间的耗氧量差异可以忽略不计。在剂量、剂量率和线性能量转移（LET）条件下，UHDR辐照在体外对胰腺癌细胞的杀伤效果与SDR相当，并在体内诱导类似的肿瘤生长延迟。这些发现强调了高let UHDR辐射的潜力，并支持了氧离子在UHDR的进一步研究。

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First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy

Within this study, we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological complexity. The difference in oxygen consumption between UHDR and standard dose rates (SDR) was negligible in a protein-enriched saline solution. For the studied conditions of dose, dose rate and linear energy transfer (LET), UHDR irradiation showed comparable efficacy to SDR in pancreatic cancer cell killing in vitro, along with inducing a similar tumor growth delay in vivo. These findings emphasize the potential of high-LET UHDR irradiation and support further investigation of oxygen ions at UHDR.

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来源期刊

Physics and Imaging in Radiation Oncology Physics and Astronomy-Radiation

CiteScore

5.30

自引率

18.90%

发文量

审稿时长

6 weeks