光诱导形式分子间烯-炔复合：通过电子供体-受体络合物的区域选择性合成铬烯衍生物。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-10 DOI:10.1021/acs.orglett.5c01700

Jie Yao, Junhua Hu, Siru Chen, Haiying Li, Linqian Li, Yuyuan He, En Long, Ting Liang, Qin Huang and Sasa Wang*,

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引用次数: 0

摘要

通过利用协同光化学和磷酸酯催化，我们开发了一种光诱导形式的烯-炔复分解协议，通过同时重组烯烃C = C和亚胺C = N键来实现区域选择性的染色质构建。通过同时形成四个新键，合成了一系列未开发的e构型的铬烯。进行了克级合成和机理研究。烯烃的无金属C = C解理揭示了这种转变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Photoinduced Formal Intermolecular Ene-Yne Metathesis: Regioselective Synthesis of Chromene Derivatives via an Electron Donor–Acceptor Complex

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Photoinduced Formal Intermolecular Ene-Yne Metathesis: Regioselective Synthesis of Chromene Derivatives via an Electron Donor–Acceptor Complex

By leveraging synergistic photochemical and phosphate ester catalysis, we developed a photoinduced formal ene-yne metathesis protocol enabling regioselective chromene construction via concurrent alkene C═C and imine C═N bond reorganization. A series of unexplored chromenes were synthesized in the E-configuration via simultaneous formation of four new bonds. Gram-scale synthesis and mechanistic studies were conducted. The metal-free C═C cleavage of alkenes sheds light on the transformation.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.