Clive H Wasserfall, Chris E Forsmark, Shuang Li, Liang Li, Phil A Hart, Mark O Goodarzi, Yogish C Kudva, Melena D Bellin, Dhiraj Yadav, Darwin L Conwell, Jose Serrano, Dana K Andersen, William Fisher, Anna Casu, Ken Cusi, Steven J Hughes, Evan Fogel, Walter Park, Stephen K Van Den Eeden
{"title":"1型糖尿病自身抗体在急性，复发急性和慢性胰腺炎。","authors":"Clive H Wasserfall, Chris E Forsmark, Shuang Li, Liang Li, Phil A Hart, Mark O Goodarzi, Yogish C Kudva, Melena D Bellin, Dhiraj Yadav, Darwin L Conwell, Jose Serrano, Dana K Andersen, William Fisher, Anna Casu, Ken Cusi, Steven J Hughes, Evan Fogel, Walter Park, Stephen K Van Den Eeden","doi":"10.2337/db24-0931","DOIUrl":null,"url":null,"abstract":"<p><strong>Article highlights: </strong>Type 1 diabetes-associated autoimmune mechanisms have not been thoroughly examined in pancreatitis-associated diabetes. We assessed the prevalence of four islet autoantibodies in serum from a large prospective cohort of patients with acute, recurrent acute, or chronic pancreatitis. Diabetes was present in 11 (12%) of 94 participants with acute pancreatitis, 69 (27%) of 273 with recurrent acute pancreatitis, and 235 (43%) of 560 with chronic pancreatitis. Excluding those with only insulin autoantibody positivity, which is confounded by insulin treatment, islet autoantibodies were identified in 51 (5.5%) of 927 participants, and 30 (3.2%) of 297 were positive for two or more autoantibodies. Our findings suggest pancreatitis may elicit islet autoimmunity in a subset of patients, necessitating prospective longitudinal follow-up.</p>","PeriodicalId":93977,"journal":{"name":"Diabetes","volume":" ","pages":"1603-1612"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365414/pdf/","citationCount":"0","resultStr":"{\"title\":\"Type 1 Diabetes Autoantibodies in Acute, Recurrent Acute, and Chronic Pancreatitis.\",\"authors\":\"Clive H Wasserfall, Chris E Forsmark, Shuang Li, Liang Li, Phil A Hart, Mark O Goodarzi, Yogish C Kudva, Melena D Bellin, Dhiraj Yadav, Darwin L Conwell, Jose Serrano, Dana K Andersen, William Fisher, Anna Casu, Ken Cusi, Steven J Hughes, Evan Fogel, Walter Park, Stephen K Van Den Eeden\",\"doi\":\"10.2337/db24-0931\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Article highlights: </strong>Type 1 diabetes-associated autoimmune mechanisms have not been thoroughly examined in pancreatitis-associated diabetes. We assessed the prevalence of four islet autoantibodies in serum from a large prospective cohort of patients with acute, recurrent acute, or chronic pancreatitis. Diabetes was present in 11 (12%) of 94 participants with acute pancreatitis, 69 (27%) of 273 with recurrent acute pancreatitis, and 235 (43%) of 560 with chronic pancreatitis. Excluding those with only insulin autoantibody positivity, which is confounded by insulin treatment, islet autoantibodies were identified in 51 (5.5%) of 927 participants, and 30 (3.2%) of 297 were positive for two or more autoantibodies. Our findings suggest pancreatitis may elicit islet autoimmunity in a subset of patients, necessitating prospective longitudinal follow-up.</p>\",\"PeriodicalId\":93977,\"journal\":{\"name\":\"Diabetes\",\"volume\":\" \",\"pages\":\"1603-1612\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365414/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2337/db24-0931\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2337/db24-0931","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Type 1 Diabetes Autoantibodies in Acute, Recurrent Acute, and Chronic Pancreatitis.
Article highlights: Type 1 diabetes-associated autoimmune mechanisms have not been thoroughly examined in pancreatitis-associated diabetes. We assessed the prevalence of four islet autoantibodies in serum from a large prospective cohort of patients with acute, recurrent acute, or chronic pancreatitis. Diabetes was present in 11 (12%) of 94 participants with acute pancreatitis, 69 (27%) of 273 with recurrent acute pancreatitis, and 235 (43%) of 560 with chronic pancreatitis. Excluding those with only insulin autoantibody positivity, which is confounded by insulin treatment, islet autoantibodies were identified in 51 (5.5%) of 927 participants, and 30 (3.2%) of 297 were positive for two or more autoantibodies. Our findings suggest pancreatitis may elicit islet autoimmunity in a subset of patients, necessitating prospective longitudinal follow-up.
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