Fernando Luis Scolari, Marciane Maria Rover, Geraldine Trott, Mariana Motta Dias da Silva, Denise de Souza, Aline Paula Miozzo, Jennifer Menna Barreto de Souza, Gabrielle Nunes da Silva, Raíne Fogliati De Carli Schardosim, Emelyn de Souza Roldão, Rosa da Rosa Minho Dos Santos, Duane Mocellin, Gabriela Soares Rech, Carolina Rothmann Itaqui, Lucas Gobetti da Luz, Gabriel Beilfuss Rieth, Thiago Costa Lisboa, Ana Carolina Mardini, Juliana Cardozo Fernandes, Bruna Oliveira Lago, Luciane Facchi, Anderson Donelli da Silveira, Igor Gorski Benedetto, Marcelle Klein Draghetti, Tiago Pacheco, Debora Vaccaro Fogazzi, Milena Soriano Marcolino, Ana Carolina Peçanha Antonio, Paulo Roberto Schvartzman, Bruna Brandao Barreto, Caroline Cabral Robinson, Maicon Falavigna, Luiz Antonio Nasi, Cassiano Teixeira, Carisi Anne Polanczyk, Regis Goulart Rosa
{"title":"covid -19相关急性呼吸窘迫综合征后的长期心肺功能：一项多中心病例对照研究","authors":"Fernando Luis Scolari, Marciane Maria Rover, Geraldine Trott, Mariana Motta Dias da Silva, Denise de Souza, Aline Paula Miozzo, Jennifer Menna Barreto de Souza, Gabrielle Nunes da Silva, Raíne Fogliati De Carli Schardosim, Emelyn de Souza Roldão, Rosa da Rosa Minho Dos Santos, Duane Mocellin, Gabriela Soares Rech, Carolina Rothmann Itaqui, Lucas Gobetti da Luz, Gabriel Beilfuss Rieth, Thiago Costa Lisboa, Ana Carolina Mardini, Juliana Cardozo Fernandes, Bruna Oliveira Lago, Luciane Facchi, Anderson Donelli da Silveira, Igor Gorski Benedetto, Marcelle Klein Draghetti, Tiago Pacheco, Debora Vaccaro Fogazzi, Milena Soriano Marcolino, Ana Carolina Peçanha Antonio, Paulo Roberto Schvartzman, Bruna Brandao Barreto, Caroline Cabral Robinson, Maicon Falavigna, Luiz Antonio Nasi, Cassiano Teixeira, Carisi Anne Polanczyk, Regis Goulart Rosa","doi":"10.1097/CCE.0000000000001286","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate long-term pulmonary function, cardiopulmonary exercise capacity, chest CT findings, and health-related quality of life (HRQoL) in survivors of COVID-19 complicated by acute respiratory distress syndrome (ARDS).</p><p><strong>Design, setting, and patients: </strong>This is a multicentric case-control study conducted from February 2023 to December of 2023. Pulmonary function tests, cardiopulmonary exercise testing (CPET), chest CT, and HRQoL (using EuroQol 5D three-level [EQ-5D-3L]) were performed at least 12 months after hospital discharge among cases (COVID-19 complicated by ARDS) and at the time of inclusion among controls (family members/friends matched for sex and age).</p><p><strong>Interventions: </strong>None.</p><p><strong>Measurements and main results: </strong>A total of 114 COVID-19 ARDS survivors and 115 controls were included. The mean age was 54 years and 52.4% of the participants were men. Time from hospital discharge to evaluation was 22 months (20.99-41.41 mo) among cases. Persistent symptoms, including memory loss (48.2%), fatigue (42.1%), and anxiety (31.6%), were reported by 73.6% of the COVID-19 ARDS survivors. Cases had significantly reduced pulmonary function, with lower diffusing capacity for carbon monoxide (DLCO) of 6.85 mmol/min/Kpa (5.44-8.37 mmol/min/Kpa) vs. 7.36 mmol/min/Kpa (6.43-8.96 mmol/min/Kpa; p = 0.012) and % of predicted DLCO of 81.0% (70.2-90.4%) vs. 89.3% (78.9-99.9%; p < 0.001), compared with controls, as well as a higher frequency of moderate to severe DLCO impairment (10.5% vs. 0.8%; p = 0.002). In CPET, cases demonstrated lower peak oxygen consumption (21.9 mL/kg/min [18.2-29 mL/kg/min] vs. 25.8 mL/kg/min [21.6-31.9 mL/kg/min]; p < 0.001). Chest CT revealed a greater prevalence of ground-glass opacities in cases (53.5% vs. 16.5%; p < 0.001) and emphysema (6.1% vs. 0%; p = 0.043). HRQoL, using EQ-5D-3L utility scores, were significantly lower in cases, with worse mobility (p < 0.001), self-care (p < 0.001), and anxiety/depression (p = 0.04) dimension scores compared with controls.</p><p><strong>Conclusions: </strong>COVID-19 ARDS survivors exhibit significant long-term impairments in pulmonary function, exercise capacity, and quality of life and abnormal chest CT findings compared with family controls with same sex and age.</p>","PeriodicalId":93957,"journal":{"name":"Critical care explorations","volume":"7 7","pages":"e1286"},"PeriodicalIF":2.7000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-Term Cardiopulmonary Function After COVID-19-Associated Acute Respiratory Distress Syndrome: A Multicenter Case-Control Study.\",\"authors\":\"Fernando Luis Scolari, Marciane Maria Rover, Geraldine Trott, Mariana Motta Dias da Silva, Denise de Souza, Aline Paula Miozzo, Jennifer Menna Barreto de Souza, Gabrielle Nunes da Silva, Raíne Fogliati De Carli Schardosim, Emelyn de Souza Roldão, Rosa da Rosa Minho Dos Santos, Duane Mocellin, Gabriela Soares Rech, Carolina Rothmann Itaqui, Lucas Gobetti da Luz, Gabriel Beilfuss Rieth, Thiago Costa Lisboa, Ana Carolina Mardini, Juliana Cardozo Fernandes, Bruna Oliveira Lago, Luciane Facchi, Anderson Donelli da Silveira, Igor Gorski Benedetto, Marcelle Klein Draghetti, Tiago Pacheco, Debora Vaccaro Fogazzi, Milena Soriano Marcolino, Ana Carolina Peçanha Antonio, Paulo Roberto Schvartzman, Bruna Brandao Barreto, Caroline Cabral Robinson, Maicon Falavigna, Luiz Antonio Nasi, Cassiano Teixeira, Carisi Anne Polanczyk, Regis Goulart Rosa\",\"doi\":\"10.1097/CCE.0000000000001286\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aimed to evaluate long-term pulmonary function, cardiopulmonary exercise capacity, chest CT findings, and health-related quality of life (HRQoL) in survivors of COVID-19 complicated by acute respiratory distress syndrome (ARDS).</p><p><strong>Design, setting, and patients: </strong>This is a multicentric case-control study conducted from February 2023 to December of 2023. Pulmonary function tests, cardiopulmonary exercise testing (CPET), chest CT, and HRQoL (using EuroQol 5D three-level [EQ-5D-3L]) were performed at least 12 months after hospital discharge among cases (COVID-19 complicated by ARDS) and at the time of inclusion among controls (family members/friends matched for sex and age).</p><p><strong>Interventions: </strong>None.</p><p><strong>Measurements and main results: </strong>A total of 114 COVID-19 ARDS survivors and 115 controls were included. The mean age was 54 years and 52.4% of the participants were men. Time from hospital discharge to evaluation was 22 months (20.99-41.41 mo) among cases. Persistent symptoms, including memory loss (48.2%), fatigue (42.1%), and anxiety (31.6%), were reported by 73.6% of the COVID-19 ARDS survivors. Cases had significantly reduced pulmonary function, with lower diffusing capacity for carbon monoxide (DLCO) of 6.85 mmol/min/Kpa (5.44-8.37 mmol/min/Kpa) vs. 7.36 mmol/min/Kpa (6.43-8.96 mmol/min/Kpa; p = 0.012) and % of predicted DLCO of 81.0% (70.2-90.4%) vs. 89.3% (78.9-99.9%; p < 0.001), compared with controls, as well as a higher frequency of moderate to severe DLCO impairment (10.5% vs. 0.8%; p = 0.002). In CPET, cases demonstrated lower peak oxygen consumption (21.9 mL/kg/min [18.2-29 mL/kg/min] vs. 25.8 mL/kg/min [21.6-31.9 mL/kg/min]; p < 0.001). Chest CT revealed a greater prevalence of ground-glass opacities in cases (53.5% vs. 16.5%; p < 0.001) and emphysema (6.1% vs. 0%; p = 0.043). HRQoL, using EQ-5D-3L utility scores, were significantly lower in cases, with worse mobility (p < 0.001), self-care (p < 0.001), and anxiety/depression (p = 0.04) dimension scores compared with controls.</p><p><strong>Conclusions: </strong>COVID-19 ARDS survivors exhibit significant long-term impairments in pulmonary function, exercise capacity, and quality of life and abnormal chest CT findings compared with family controls with same sex and age.</p>\",\"PeriodicalId\":93957,\"journal\":{\"name\":\"Critical care explorations\",\"volume\":\"7 7\",\"pages\":\"e1286\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Critical care explorations\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/CCE.0000000000001286\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical care explorations","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/CCE.0000000000001286","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Long-Term Cardiopulmonary Function After COVID-19-Associated Acute Respiratory Distress Syndrome: A Multicenter Case-Control Study.
Objectives: This study aimed to evaluate long-term pulmonary function, cardiopulmonary exercise capacity, chest CT findings, and health-related quality of life (HRQoL) in survivors of COVID-19 complicated by acute respiratory distress syndrome (ARDS).
Design, setting, and patients: This is a multicentric case-control study conducted from February 2023 to December of 2023. Pulmonary function tests, cardiopulmonary exercise testing (CPET), chest CT, and HRQoL (using EuroQol 5D three-level [EQ-5D-3L]) were performed at least 12 months after hospital discharge among cases (COVID-19 complicated by ARDS) and at the time of inclusion among controls (family members/friends matched for sex and age).
Interventions: None.
Measurements and main results: A total of 114 COVID-19 ARDS survivors and 115 controls were included. The mean age was 54 years and 52.4% of the participants were men. Time from hospital discharge to evaluation was 22 months (20.99-41.41 mo) among cases. Persistent symptoms, including memory loss (48.2%), fatigue (42.1%), and anxiety (31.6%), were reported by 73.6% of the COVID-19 ARDS survivors. Cases had significantly reduced pulmonary function, with lower diffusing capacity for carbon monoxide (DLCO) of 6.85 mmol/min/Kpa (5.44-8.37 mmol/min/Kpa) vs. 7.36 mmol/min/Kpa (6.43-8.96 mmol/min/Kpa; p = 0.012) and % of predicted DLCO of 81.0% (70.2-90.4%) vs. 89.3% (78.9-99.9%; p < 0.001), compared with controls, as well as a higher frequency of moderate to severe DLCO impairment (10.5% vs. 0.8%; p = 0.002). In CPET, cases demonstrated lower peak oxygen consumption (21.9 mL/kg/min [18.2-29 mL/kg/min] vs. 25.8 mL/kg/min [21.6-31.9 mL/kg/min]; p < 0.001). Chest CT revealed a greater prevalence of ground-glass opacities in cases (53.5% vs. 16.5%; p < 0.001) and emphysema (6.1% vs. 0%; p = 0.043). HRQoL, using EQ-5D-3L utility scores, were significantly lower in cases, with worse mobility (p < 0.001), self-care (p < 0.001), and anxiety/depression (p = 0.04) dimension scores compared with controls.
Conclusions: COVID-19 ARDS survivors exhibit significant long-term impairments in pulmonary function, exercise capacity, and quality of life and abnormal chest CT findings compared with family controls with same sex and age.
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