Jaehyun Ahn, Joonseok Kim, Christopher Shin, Stephen Ahn
{"title":"成人胶质瘤患者的人体测量学、癌症风险和生存结果——一项系统综述和荟萃分析。","authors":"Jaehyun Ahn, Joonseok Kim, Christopher Shin, Stephen Ahn","doi":"10.1007/s00701-025-06579-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The association between anthropometric measures including BMI, height and cancer has been widely discussed. However, the role of these in the development and prognosis of glioma remains controversial. We aimed to study these relationships.</p><p><strong>Methods: </strong>We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. Papers reporting relationship between anthropometric measures and the risk of glioma, both incidence and survival, were considered relevant. Those published until January 31, 2024, were selected from PubMed, EMBASE, and the Cochrane Library. Studies were evaluated according to the modified Newcastle Ottawa Scale. Hazard ratios, relative risks, and 95% confidence intervals were pooled and synthesized using a random effects model.</p><p><strong>Results: </strong>Among 940 screened articles, 23 were selected. Taller height was significantly associated with an increased risk of both glioma (HR per 10 cm, 1.19; CI, 1.16 to 1.23) and glioblastoma (HR per 10 cm, 1.25; CI, 1.18 to 1.31). Higher BMI was positively correlated with an increased risk of glioma, both in categorical (RR, 1.08; CI, 1.03 to 1.12) and continuous measures (HR per 5 kg/m<sup>2</sup>, 1.01; CI, 1.00 to 1.03). Glioblastoma demonstrated a higher incidence risk (HR per 5 kg/m<sup>2</sup>, 1.02; 95% CI 1.00 to 1.05) and better survival outcomes (HR 0.75; 95% CI 0.59 to 0.96) with increasing BMI.</p><p><strong>Conclusion: </strong>This study provides critical insights into the relationship between glioma and anthropometric measures. Glioma and glioblastoma were associated with these measures in terms of both incidence and survival. Further research is necessary to uncover the mechanisms and develop preventative or therapeutic strategies.</p>","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":"167 1","pages":"188"},"PeriodicalIF":1.9000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241189/pdf/","citationCount":"0","resultStr":"{\"title\":\"Anthropometrics, cancer risks, and survival outcomes in adult patients with glioma - a systematic review and meta-analysis.\",\"authors\":\"Jaehyun Ahn, Joonseok Kim, Christopher Shin, Stephen Ahn\",\"doi\":\"10.1007/s00701-025-06579-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The association between anthropometric measures including BMI, height and cancer has been widely discussed. However, the role of these in the development and prognosis of glioma remains controversial. We aimed to study these relationships.</p><p><strong>Methods: </strong>We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. Papers reporting relationship between anthropometric measures and the risk of glioma, both incidence and survival, were considered relevant. Those published until January 31, 2024, were selected from PubMed, EMBASE, and the Cochrane Library. Studies were evaluated according to the modified Newcastle Ottawa Scale. Hazard ratios, relative risks, and 95% confidence intervals were pooled and synthesized using a random effects model.</p><p><strong>Results: </strong>Among 940 screened articles, 23 were selected. Taller height was significantly associated with an increased risk of both glioma (HR per 10 cm, 1.19; CI, 1.16 to 1.23) and glioblastoma (HR per 10 cm, 1.25; CI, 1.18 to 1.31). Higher BMI was positively correlated with an increased risk of glioma, both in categorical (RR, 1.08; CI, 1.03 to 1.12) and continuous measures (HR per 5 kg/m<sup>2</sup>, 1.01; CI, 1.00 to 1.03). Glioblastoma demonstrated a higher incidence risk (HR per 5 kg/m<sup>2</sup>, 1.02; 95% CI 1.00 to 1.05) and better survival outcomes (HR 0.75; 95% CI 0.59 to 0.96) with increasing BMI.</p><p><strong>Conclusion: </strong>This study provides critical insights into the relationship between glioma and anthropometric measures. Glioma and glioblastoma were associated with these measures in terms of both incidence and survival. Further research is necessary to uncover the mechanisms and develop preventative or therapeutic strategies.</p>\",\"PeriodicalId\":7370,\"journal\":{\"name\":\"Acta Neurochirurgica\",\"volume\":\"167 1\",\"pages\":\"188\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241189/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Neurochirurgica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00701-025-06579-4\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Neurochirurgica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00701-025-06579-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Anthropometrics, cancer risks, and survival outcomes in adult patients with glioma - a systematic review and meta-analysis.
Purpose: The association between anthropometric measures including BMI, height and cancer has been widely discussed. However, the role of these in the development and prognosis of glioma remains controversial. We aimed to study these relationships.
Methods: We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. Papers reporting relationship between anthropometric measures and the risk of glioma, both incidence and survival, were considered relevant. Those published until January 31, 2024, were selected from PubMed, EMBASE, and the Cochrane Library. Studies were evaluated according to the modified Newcastle Ottawa Scale. Hazard ratios, relative risks, and 95% confidence intervals were pooled and synthesized using a random effects model.
Results: Among 940 screened articles, 23 were selected. Taller height was significantly associated with an increased risk of both glioma (HR per 10 cm, 1.19; CI, 1.16 to 1.23) and glioblastoma (HR per 10 cm, 1.25; CI, 1.18 to 1.31). Higher BMI was positively correlated with an increased risk of glioma, both in categorical (RR, 1.08; CI, 1.03 to 1.12) and continuous measures (HR per 5 kg/m2, 1.01; CI, 1.00 to 1.03). Glioblastoma demonstrated a higher incidence risk (HR per 5 kg/m2, 1.02; 95% CI 1.00 to 1.05) and better survival outcomes (HR 0.75; 95% CI 0.59 to 0.96) with increasing BMI.
Conclusion: This study provides critical insights into the relationship between glioma and anthropometric measures. Glioma and glioblastoma were associated with these measures in terms of both incidence and survival. Further research is necessary to uncover the mechanisms and develop preventative or therapeutic strategies.
期刊介绍：
The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.
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