带电极-骨骼肌电刺激对健康青年腓肠肌微血管反应性的急性影响

IF 2.7 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Microvascular research Pub Date : 2025-07-08 DOI:10.1016/j.mvr.2025.104840

Hajime Tamiya , Hina Kawashiri , Toshiaki Miyamoto , Yuko Kurosawa , Takafumi Hamaoka , Atsuhiro Tsubaki

{"title":"带电极-骨骼肌电刺激对健康青年腓肠肌微血管反应性的急性影响","authors":"Hajime Tamiya , Hina Kawashiri , Toshiaki Miyamoto , Yuko Kurosawa , Takafumi Hamaoka , Atsuhiro Tsubaki","doi":"10.1016/j.mvr.2025.104840","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>Belt electrode-skeletal muscle electrical stimulation (B-SES) improves muscle strength, mass, and exercise tolerance. However, its effects on skeletal muscle microvascular responsiveness remain unclear. In this study, we investigated the acute effects of a single B-SES session on gastrocnemius microvascular responsiveness in healthy young men.</div></div><div><h3>Methods</h3><div>In this randomized crossover study, 12 healthy young men (mean age: 20.8 ± 1.0 years) underwent two 20-min conditions: electrical stimulation at the sensory threshold (Sham, <em>n</em> = 12) and at the maximum intensity not causing discomfort (B-SES, n = 12). Gastrocnemius metabolic rate (tissue oxygen saturation [StO<sub>2</sub>] downslope) and microvascular reperfusion rate (StO<sub>2</sub> upslope) were assessed using near-infrared spectroscopy and a vascular occlusion test.</div></div><div><h3>Results</h3><div>In the B-SES condition, the StO<sub>2</sub> downslope significantly steepened (Pre: −0.15 ± 0.03 %·s<sup>−1</sup>, Post: −0.20 ± 0.03 %·s<sup>−1</sup>, <em>p</em> = 0.002). The StO<sub>2</sub> upslope also significantly steepened (Pre: 1.58 ± 0.52 %·s<sup>−1</sup>, Post: 2.56 ± 0.71 %·s<sup>−1</sup>, <em>p</em> < 0.001). A significant negative correlation was observed between the StO<sub>2</sub> downslope and StO<sub>2</sub> upslope (<em>r</em> = −0.581, <em>p</em> = 0.047). No significant changes were observed in the Sham condition.</div></div><div><h3>Conclusions</h3><div>A single B-SES session applied to the lower extremity significantly increased gastrocnemius metabolic rate and was associated with enhanced microvascular reperfusion. These findings suggest B-SES may be a useful therapeutic approach to improving microvascular responsiveness, particularly in individuals with limited exercise capacity.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"161 ","pages":"Article 104840"},"PeriodicalIF":2.7000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Acute effects of belt electrode-skeletal muscle electrical stimulation on microvascular responsiveness of the gastrocnemius muscle in healthy young men\",\"authors\":\"Hajime Tamiya , Hina Kawashiri , Toshiaki Miyamoto , Yuko Kurosawa , Takafumi Hamaoka , Atsuhiro Tsubaki\",\"doi\":\"10.1016/j.mvr.2025.104840\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>Belt electrode-skeletal muscle electrical stimulation (B-SES) improves muscle strength, mass, and exercise tolerance. However, its effects on skeletal muscle microvascular responsiveness remain unclear. In this study, we investigated the acute effects of a single B-SES session on gastrocnemius microvascular responsiveness in healthy young men.</div></div><div><h3>Methods</h3><div>In this randomized crossover study, 12 healthy young men (mean age: 20.8 ± 1.0 years) underwent two 20-min conditions: electrical stimulation at the sensory threshold (Sham, <em>n</em> = 12) and at the maximum intensity not causing discomfort (B-SES, n = 12). Gastrocnemius metabolic rate (tissue oxygen saturation [StO<sub>2</sub>] downslope) and microvascular reperfusion rate (StO<sub>2</sub> upslope) were assessed using near-infrared spectroscopy and a vascular occlusion test.</div></div><div><h3>Results</h3><div>In the B-SES condition, the StO<sub>2</sub> downslope significantly steepened (Pre: −0.15 ± 0.03 %·s<sup>−1</sup>, Post: −0.20 ± 0.03 %·s<sup>−1</sup>, <em>p</em> = 0.002). The StO<sub>2</sub> upslope also significantly steepened (Pre: 1.58 ± 0.52 %·s<sup>−1</sup>, Post: 2.56 ± 0.71 %·s<sup>−1</sup>, <em>p</em> < 0.001). A significant negative correlation was observed between the StO<sub>2</sub> downslope and StO<sub>2</sub> upslope (<em>r</em> = −0.581, <em>p</em> = 0.047). No significant changes were observed in the Sham condition.</div></div><div><h3>Conclusions</h3><div>A single B-SES session applied to the lower extremity significantly increased gastrocnemius metabolic rate and was associated with enhanced microvascular reperfusion. These findings suggest B-SES may be a useful therapeutic approach to improving microvascular responsiveness, particularly in individuals with limited exercise capacity.</div></div>\",\"PeriodicalId\":18534,\"journal\":{\"name\":\"Microvascular research\",\"volume\":\"161 \",\"pages\":\"Article 104840\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microvascular research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0026286225000597\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microvascular research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0026286225000597","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

摘要

目的：带状电极-骨骼肌电刺激（B-SES）可以提高肌肉力量、质量和运动耐受性。然而，其对骨骼肌微血管反应性的影响尚不清楚。在这项研究中，我们调查了单次B-SES对健康年轻男性腓肠肌微血管反应性的急性影响。方法在这项随机交叉研究中，12名健康年轻男性（平均年龄：20.8±1.0岁）接受了两种20分钟的条件：感觉阈值电刺激（Sham, n = 12）和不引起不适的最大强度电刺激（B-SES, n = 12）。采用近红外光谱和血管闭塞试验评估腓肠肌代谢率（组织氧饱和度[StO2]下坡）和微血管再灌注率（StO2上坡）。结果在B-SES条件下，StO2下坡明显变陡（Pre:−0.15±0.03%·s−1,Post:−0.20±0.03%·s−1,p = 0.002）。StO2上坡也显著变陡(Pre: 1.58±0.52%·s−1,Post: 2.56±0.71%·s−1,p <；0.001)。StO2下坡与StO2上坡呈显著负相关（r = - 0.581, p = 0.047）。假手术组未见明显变化。结论下肢单次B-SES治疗可显著提高腓肠肌代谢率，微血管再灌注增强。这些发现表明，B-SES可能是改善微血管反应性的有效治疗方法，特别是对于运动能力有限的个体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Acute effects of belt electrode-skeletal muscle electrical stimulation on microvascular responsiveness of the gastrocnemius muscle in healthy young men

Purpose

Belt electrode-skeletal muscle electrical stimulation (B-SES) improves muscle strength, mass, and exercise tolerance. However, its effects on skeletal muscle microvascular responsiveness remain unclear. In this study, we investigated the acute effects of a single B-SES session on gastrocnemius microvascular responsiveness in healthy young men.

Methods

In this randomized crossover study, 12 healthy young men (mean age: 20.8 ± 1.0 years) underwent two 20-min conditions: electrical stimulation at the sensory threshold (Sham, n = 12) and at the maximum intensity not causing discomfort (B-SES, n = 12). Gastrocnemius metabolic rate (tissue oxygen saturation [StO₂] downslope) and microvascular reperfusion rate (StO₂ upslope) were assessed using near-infrared spectroscopy and a vascular occlusion test.

Results

In the B-SES condition, the StO₂ downslope significantly steepened (Pre: −0.15 ± 0.03 %·s⁻¹, Post: −0.20 ± 0.03 %·s⁻¹, p = 0.002). The StO₂ upslope also significantly steepened (Pre: 1.58 ± 0.52 %·s⁻¹, Post: 2.56 ± 0.71 %·s⁻¹, p < 0.001). A significant negative correlation was observed between the StO₂ downslope and StO₂ upslope (r = −0.581, p = 0.047). No significant changes were observed in the Sham condition.

Conclusions

A single B-SES session applied to the lower extremity significantly increased gastrocnemius metabolic rate and was associated with enhanced microvascular reperfusion. These findings suggest B-SES may be a useful therapeutic approach to improving microvascular responsiveness, particularly in individuals with limited exercise capacity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Microvascular research 医学-外周血管病

CiteScore

6.00

自引率

3.20%

发文量

158

审稿时长

43 days

期刊介绍： Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.