Manal A. Abbas, Aya Y. Al-Kabariti, Randa El-Rayyes, Razan Obeidat, Abd-Alrahman Al-Rayyes
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TRPC1 and TRPC5 in Colorectal Cancer: Mechanisms, Prognostic Markers, and Therapeutic Targets
Colorectal cancer (CRC) is one of the most frequent and deadliest cancers worldwide, ranking third in prevalence and second in cancer-related deaths. Treating CRC remains a major challenge due to several factors: many cases are diagnosed at advanced stages, variable response to treatment due to genetic differences in patients, chemotherapy resistance, and the adverse effects of existing therapies. This highlights the urgent need for early diagnostic markers and effective treatments with fewer side effects. Recent research has identified transient receptor potential canonical (TRPC) channels as key regulators in the development and progression of cancer, although their specific role in CRC is not yet fully characterized. This review summarizes TRPCs pathophysiological functions, signaling pathways, interactions with other calcium channels, and their potential use as diagnostic and prognostic tools in clinical practice. Special emphasis is given to TRPC1 and TRPC5, as they represent the most extensively studied members of the TRPC family. This review also discusses potential therapeutic approaches targeting them, offering valuable insights for further advances in CRC research.
期刊介绍：
Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on medicinal chemistry, pharmacology, biotechnology and biopharmaceuticals, toxicology, and drug delivery, formulation, and pharmacokinetics. The journal welcomes manuscripts on new compounds and technologies in all areas focused on human therapeutics, as well as global management, health care policy, and regulatory issues involving the drug discovery and development process. In addition to full-length articles, Drug Development Research publishes Brief Reports on important and timely new research findings, as well as in-depth review articles. The journal also features periodic special thematic issues devoted to specific compound classes, new technologies, and broad aspects of drug discovery and development.
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