一种新的经皮胆道与可生物降解支架治疗儿童活体肝移植后肝内胆道狭窄。

IF 0.7 4区 医学 Q4 TRANSPLANTATION
Leonardo Montes, Florencia Fernandez, Florencia Agostinelli, Lucia Novellis, Juan Fasolo, Maria Solaegui, Carolina Rumbo, Diego Ramisch, Gabriel Gondolesi, Pablo Barros Schelotto
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引用次数: 0

摘要

胆道并发症是活体供肝移植后发病率的重要来源,特别是在儿科患者中。这些并发症受移植物类型、胆管解剖和重建技术的影响。对于肝空肠吻合术,经皮介入治疗是首选。在这里,我们报告了一个成功使用经皮生物可降解支架治疗肝内胆道狭窄的病例报告,该患者曾因胆道闭锁接受活体肝移植,从而创造了一条新的胆道。术后患者以胆道S2段狭窄为主,常规内引流难治性。我们通过微创手术在肝内管和肠袢之间建立了一条新的胆道。生物可降解支架在逐渐降解的同时提供暂时的结构支持,从而消除了移除的需要,并将长期并发症降至最低。随访18个月,患者无症状,肝功能检查满意,无再狭窄迹象。本病例说明了在儿童肝移植受者中应用可生物降解支架的可行性、安全性和潜在益处。研究结果表明,可生物降解支架在儿童复杂胆道并发症的治疗中可能是一个重大的进步,尽管需要进一步的研究来确定这种治疗的长期疗效和规范方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A New Percutaneous Biliary Path With a Biodegradable Stent for Intrahepatic Biliary Stenosis After Living Donor Pediatric Liver Transplant.

Biliary tract complications are a significant source of morbidity following living donor liver transplant, especially in pediatric patients. These complications are influenced by graft type, bile duct anatomy, and reconstruction techniques. For a hepaticojejunostomy, percutaneous intervention is the first option preferred. Here, we present a case report of the successful use of a percutaneous biodegradable stent to manage an intrahepatic biliary stricture in an 8-month-old patient who had previously undergone living donor liver transplant for biliary atresia, thereby creating a new biliary path. The patient developed a dominant biliary stricture of segment S2 postoperatively, which was refractory to conventional internal drainage. We created a new biliary path via a novel connection between the intrahepatic duct and the intestinal loop with minimally invasive surgery. The biodegradable stent provided temporary structural support while gradually degrading, which eliminated the need for removal and minimized long-term complications. At 18 month follow-up, the patient remained asymptomatic with satisfactory liver function tests and no evidence of restenosis. This case illustrates the feasibility, safety, and potential benefits of biodegradable stents in pediatric liver transplant recipients. The findings suggest that biodegradable stents could represent a significant advancement in the management of complex biliary tract complications in children, although further studies are necessary to establish the long-term efficacy of this treatment and standardize the protocols.

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来源期刊
CiteScore
1.40
自引率
11.10%
发文量
258
审稿时长
6-12 weeks
期刊介绍: The scope of the journal includes the following: Surgical techniques, innovations, and novelties; Immunobiology and immunosuppression; Clinical results; Complications; Infection; Malignancies; Organ donation; Organ and tissue procurement and preservation; Sociological and ethical issues; Xenotransplantation.
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