脑血管介导的神经血管耦合的动态改变:抑郁症的一个关键病理机制。

IF 6.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Xiaoyun Yang, Jiaxin Wang, Jiahao Zhang, Mengjie Zhang, Anran Hao, Feng Guo, Xueying Huang, Jinlan Yan, Yuanjia Zheng, Yucen Xia, Taiyi Wang, Meng Zhang, Ning Weng, Yongjun Chen, Lin Yao
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引用次数: 0

摘要

神经血管耦合(NVC)是一种重要的调节机制,它使神经活动与血管反应同步,以支持脑功能。尽管NVC的确切机制尚未完全阐明,但其功能障碍越来越多地与各种神经系统疾病的发病机制有关。本文综述了血管级联的最新进展,重点介绍了NVC的关键动态调节因子,包括机械力和血流介导的扩散信号。我们探索血管和神经元之间复杂的双向相互作用,强调它们在神经血管调节中的相互依存作用。以重度抑郁症(MDD)为例,我们进一步讨论了将血管功能障碍和NVC受损与MDD病理生理联系起来的新证据。这些发现将NVC定位为有希望的情绪障碍治疗靶点,强调了血流动力学信号在神经血管调节中的关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression.

Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression.

Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression.

Neurovascular coupling (NVC) is a vital regulatory mechanism that synchronizes neural activity with vascular responses to support brain function. Although the precise mechanisms of NVC remain incompletely elucidated, its dysfunction is increasingly implicated in the pathogenesis of various neurological disorders. This review synthesizes recent advancements in understanding the vascular cascade, emphasizing key dynamic regulators of NVC, including mechanical forces and diffusible signals mediated by blood flow. We explore the intricate bidirectional interactions between the vasculature and neurons, highlighting their interdependent roles in neurovascular regulation. Using major depressive disorder (MDD) as a case study, we further discuss emerging evidence linking vascular dysfunction and impaired NVC to MDD pathophysiology. These insights position NVC as a promising therapeutic target for emotional disorders, underscoring the pivotal roles of hemodynamic signaling in neurovascular regulation.

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来源期刊
Cell and Bioscience
Cell and Bioscience BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
10.70
自引率
0.00%
发文量
187
审稿时长
>12 weeks
期刊介绍: Cell and Bioscience, the official journal of the Society of Chinese Bioscientists in America, is an open access, peer-reviewed journal that encompasses all areas of life science research.
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