[TNFRSF11B基因rs2073618和rs3102735多态性与胃癌易感性的关系]。

Q4 Medicine

中华医学遗传学杂志 Pub Date : 2025-05-10 DOI:10.3760/cma.j.cn511374-20241013-00551

Xuan Tang, Dandan Gong, Shiqi Zhang, Xiaoyan Wang, Yu Fan

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引用次数: 0

摘要

目的：探讨TNFRSF11B基因rs2073618和rs3102735单核苷酸多态性与胃癌易感性的关系。方法：采用病例对照研究。选取2013年5月至2017年6月在镇江市第一人民医院接受治疗的原发性胃癌患者577例作为病例组，选取同期在同一医院接受体检的健康个体678例作为对照组。采集两组患者的血样，提取基因组DNA。采用PCR扩增目的基因片段，采用Snapshot技术进行基因分型。采用SPSS v2.0软件进行统计分析。本研究经镇江市第一人民医院医学伦理委员会批准（伦理号：20150083）。结果：病例组吸烟率明显高于对照组（P = 0.006）。TNFRSF11B基因rs3102735位点T>C多态性与胃癌发生风险增加显著相关（CC vs TT: OR = 2.164, 95%CI = 1.063~4.406, P = 0.030）。而rs2073618多态性与胃癌易感性无显著相关性（P < 0.05）。年龄、性别、吸烟状况、饮酒状况分层分析显示rs2073618多态性与胃癌易感性无显著相关性（P < 0.05）。然而，rs3102735多态性与62岁以上个体的胃癌风险有显著相关性（CC vs TT: OR = 5.44, 95%CI = 1.54~19.21, P = 0.003）。结论：TNFRSF11B基因rs3102735多态性可能与胃癌易感性有关，尤其是在老年人群中。这种多态性可以作为鉴别胃癌高危人群的潜在指标。

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[Association of TNFRSF11B gene rs2073618 and rs3102735 polymorphisms with susceptibility to Gastric cancer].

Objective: To explore the association between single nucleotide polymorphism (SNP) rs2073618 and rs3102735 of the TNFRSF11B gene and the susceptibility to gastric cancer.

Methods: A case-control study was conducted. A total of 577 patients with primary gastric cancer treated at Zhenjiang First People's Hospital from May 2013 to June 2017 were selected as the case group, and 678 healthy individuals who underwent physical examinations at the same hospital during the same period were enrolled as the control group. Blood samples were collected from both groups, and genomic DNA was extracted. The target gene fragments were amplified using PCR, and genotyping was performed using the Snapshot technique. Statistical analysis was conducted using SPSS v2.0 software. This study was approved by the Medical Ethics Committee of the Zhenjiang First People's Hospital (Ethics No. 20150083).

Results: The smoking rate was significantly higher in the case group than in the control group (P = 0.006). The T>C polymorphism at the rs3102735 locus of the TNFRSF11B gene was significantly associated with an increased risk of gastric cancer (CC vs. TT: OR = 2.164, 95%CI = 1.063~4.406, P = 0.030). In contrast, the rs2073618 polymorphism did not show a significant association with gastric cancer susceptibility (P > 0.05). Stratified analysis by age, gender, smoking status, and drinking status revealed no significant association between the rs2073618 polymorphism and gastric cancer susceptibility (P > 0.05). However, the rs3102735 polymorphism showed a significant association with gastric cancer risk in individuals over 62 years of age (CC vs. TT: OR = 5.44, 95%CI = 1.54~19.21, P = 0.003).

Conclusion: The rs3102735 polymorphism of the TNFRSF11B gene may be associated with susceptibility to gastric cancer, particularly in older populations. This polymorphism could serve as a potential indicator for identifying high-risk groups for gastric cancer.

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来源期刊

中华医学遗传学杂志 Medicine-Medicine (all)

CiteScore

0.50

自引率

0.00%

发文量

9521

期刊介绍： Chinese Journal of Medical Genetics is a medical journal, founded in 1984, under the supervision of the China Association for Science and Technology, sponsored by the Chinese Medical Association (hosted by Sichuan University), and is now a monthly magazine, which attaches importance to academic orientation, adheres to the scientific, scholarly, advanced, and innovative, and has a certain degree of influence in the industry. Chinese Journal of Medical Genetics is a journal of Peking University, and is now included in Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of Chinese Science Citation Database (with extended version), Statistical Source Journals (China Science and Technology Dissertation Outstanding Journals), Zhi.com (in Chinese), Wipu (in Chinese), Wanfang (in Chinese), CA Chemical Abstracts (U.S.), JST (Japan Science and Technology Science and Technology), and JST (Japan Science and Technology Science and Technology Research Center). ), JST (Japan Science and Technology Agency), Pж (AJ) Abstracts Journal (Russia), Copernicus Index (Poland), Cambridge Scientific Abstracts, Abstracts and Citation Database, Abstracts Magazine, Medical Abstracts, and so on.