电化疗治疗肛肠肿瘤:叙述性文献综述。

IF 2.8 4区 医学 Q3 ONCOLOGY
Technology in Cancer Research & Treatment Pub Date : 2025-01-01 Epub Date: 2025-07-08 DOI:10.1177/15330338251349596
Martina Ferioli, Alessandra Arcelli, Savino Cilla, Arina A Zamfir, Giorgio Tolento, Dajana Cuicchi, Milly Buwenge, Erika Galietta, Bruno Fionda, Luca Tagliaferri, Matteo Rottoli, Gilberto Poggioli, Alessio G Morganti
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引用次数: 0

摘要

这篇叙述性的综述探讨了电化疗(ECT)在治疗肛肠肿瘤中的潜在作用,重点是其有效性、可行性和相关的毒性。ECT结合了化疗和电场的应用来增强肿瘤细胞对药物的吸收,已经显示出作为局部治疗的希望,特别是在传统疗法如放疗已经用尽或不适合的情况下。根据SANRA的指导方针进行的审查,包括18项关于电痉挛治疗肛肠肿瘤的研究,从狗的临床前试验到病例报告和人类临床研究。研究结果表明,ECT可以实现高肿瘤总有效率(70-100%),副作用最小,具有肿瘤缩小和器官功能保存等优点。这些结果突出了ECT的潜力,不仅提供肿瘤减少,而且在毒性相对较低的情况下保存重要的器官功能。然而,需要进一步的比较研究来证实其作为标准治疗选择的作用。此外,由于研究的显著异质性,样本量小,以及缺乏与放疗和冷冻手术等其他局部治疗的比较研究,证据受到限制。因此,虽然ECT似乎是一个有希望的选择,特别是在姑息治疗或新辅助设置,它还不能推荐作为标准治疗。未来的研究应该集中在更大的、更可靠的、标准化结果的研究上,并探索电痉挛疗法和其他疗法之间的潜在协同作用,以确立其在肛肠肿瘤治疗中的地位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Electrochemotherapy for Anorectal Tumors: A Narrative Literature Review.

Electrochemotherapy for Anorectal Tumors: A Narrative Literature Review.

Electrochemotherapy for Anorectal Tumors: A Narrative Literature Review.

Electrochemotherapy for Anorectal Tumors: A Narrative Literature Review.

This narrative review explores the potential role of electrochemotherapy (ECT) in treating anorectal tumors, focusing on its effectiveness, feasibility, and associated toxicities. ECT, which combines chemotherapy with the application of an electric field to enhance drug uptake by tumor cells, has shown promise as a local treatment, particularly in cases where conventional therapies such as radiotherapy have been exhausted or are unsuitable. The review, conducted according to SANRA guidelines, included 18 studies, on ECT in anorectal tumors, ranging from preclinical trials in dogs to case reports and clinical studies in humans. The findings indicate that ECT can achieve high tumor overall response rates (70-100%) with minimal side effects, offering benefits such as tumor reduction and preserved organ function. These results highlight the potential of ECT to provide not only tumor reduction but also the preservation of vital organ function with a relatively low toxicity profile. However, further comparative research is necessary to substantiate its role as a standard therapeutic option. Moreover, the evidence is limited by significant heterogeneity across studies, small sample sizes, and a lack of comparative research with other local treatments like radiotherapy and cryosurgery. Consequently, while ECT appears to be a promising option, particularly for palliative care or in a neoadjuvant setting, it cannot yet be recommended as a standard treatment. Future research should focus on larger, more robust studies with standardized outcomes and explore the potential synergy between ECT and other therapies to establish its place in the treatment of anorectal tumors.

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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
202
审稿时长
2 months
期刊介绍: Technology in Cancer Research & Treatment (TCRT) is a JCR-ranked, broad-spectrum, open access, peer-reviewed publication whose aim is to provide researchers and clinicians with a platform to share and discuss developments in the prevention, diagnosis, treatment, and monitoring of cancer.
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