在肺损伤小鼠模型中,β-葡聚糖通过中性粒细胞/IFNγ轴重编程肺泡巨噬细胞。

IF 6.4 1区 生物学 Q1 BIOLOGY
eLife Pub Date : 2025-07-08 DOI:10.7554/eLife.102068
Renaud Prevel, Erwan Pernet, Kim A Tran, Abderrahmane Sadek, Mina Sadeghi, Elizabeth Lapshina, Leonardo F Jurado, Arnold S Kristof, Mohieddine Moumni, Jeremie Poschmann, Maziar Divangahi
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引用次数: 0

摘要

肺泡巨噬细胞(AMs)存在于下气道,在肺部健康和对无菌炎症和感染的反应中起着至关重要的作用。人工智能对不同的环境挑战具有显著的适应性,这种适应性可以通过其记忆能力(训练后的免疫力)持续存在。β-葡聚糖被认为是通过骨髓造血干细胞重编程中枢训练免疫的有效诱导剂。在本研究中,我们发现小鼠全身给药β-葡聚糖通过重新编程肺部的AMs,以不依赖于dectin1的方式诱导外周训练免疫。我们进一步证明,AM在转录和代谢水平上的重编程,通过嗜中性粒细胞/IFN-γ依赖的方式,加剧了细菌(脂多糖)或病毒(polyI:C)攻击后的肺损伤。这些发现确定了β-葡聚糖在训练免疫中涉及AM重编程的另一个方面,并阐明了训练免疫的潜在有害影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury.

Alveolar macrophages (AMs) reside in the lower airways and play a crucial role in lung health and response to sterile inflammation and infections. AMs possess remarkable adaptability to different environmental challenges that can persist through their memory capacity (trained immunity). β-Glucan has been characterized as a potent inducer of central trained immunity by reprogramming haematopoietic stem cells in the bone marrow. In the present study, we show that systemic administration of β-glucan in mice induces peripheral trained immunity by reprogramming AMs in the lungs, in a Dectin1-independent manner. We furthermore demonstrate that AM reprogramming at both the transcriptional and metabolic levels exacerbate lung injury following bacterial (lipopolysaccharide) or viral (polyI:C) challenges via a neutrophil/IFN-γ-dependent manner. These findings identify an additional facet of β-glucan in trained immunity involving AM reprogramming and shed light on the potential detrimental effects of trained immunity.

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来源期刊
eLife
eLife BIOLOGY-
CiteScore
12.90
自引率
3.90%
发文量
3122
审稿时长
17 weeks
期刊介绍: eLife is a distinguished, not-for-profit, peer-reviewed open access scientific journal that specializes in the fields of biomedical and life sciences. eLife is known for its selective publication process, which includes a variety of article types such as: Research Articles: Detailed reports of original research findings. Short Reports: Concise presentations of significant findings that do not warrant a full-length research article. Tools and Resources: Descriptions of new tools, technologies, or resources that facilitate scientific research. Research Advances: Brief reports on significant scientific advancements that have immediate implications for the field. Scientific Correspondence: Short communications that comment on or provide additional information related to published articles. Review Articles: Comprehensive overviews of a specific topic or field within the life sciences.
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