COVID-19急性后后遗症的免疫学和临床标志物:来自感染后6个月的轻、重度病例的见解

IF 3.7 3区 医学 Q2 IMMUNOLOGY
William Mouton, Sophia Djebali, Marine Villard, Omran Allatif, Cécile Chauvel, Sarah Benezech, Philippe Vanhems, Jacqueline Marvel, Thierry Walzer, Sophie Trouillet-Assant
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引用次数: 0

摘要

COVID-19急性后后遗症(PASC)是一种复杂的临床疾病,需要更好地了解其潜在的生物学机制。在这项研究中,我们评估了两组患者的数百种病毒学、血清学、免疫学和组织损伤生物标志物,这些患者在初次感染后6至9个月经历了轻度(n = 270)或重度(n = 188) COVID-19,其中40%和57.4%的患者分别发展为PASC。血液分析显示,体液、病毒和生物标志物的主要差异与最初的COVID-19严重程度有关,而不是与PASC特异性相关。然而,PASC患者表现出CD4+和CD8+记忆T细胞亚群改变,细胞因子分泌细胞增多,终末分化的CD45RA+效应记忆T细胞(TEMRA)增多。还观察到对TEMRA表型的核衣壳/膜蛋白有反应的sars - cov -2特异性T细胞升高。随机森林模型将这些特征和初始症状持续时间作为判别PASC的首要变量,实现了80%以上的分类准确率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Immunological and Clinical Markers of Post-acute Sequelae of COVID-19: Insights from Mild and Severe Cases 6 Months Post-infection

Immunological and Clinical Markers of Post-acute Sequelae of COVID-19: Insights from Mild and Severe Cases 6 Months Post-infection

Post-acute sequelae of COVID-19 (PASC) are a complex clinical condition that requires a better understanding of its underlying biological mechanisms. In this study, we assessed hundreds of virological, serological, immunological, and tissue damage biomarkers in two cohorts of patients who had experienced either mild (n = 270) or severe (n = 188) COVID-19, 6 to 9 months post-initial infection, and in which 40% and 57.4% of patients, respectively, developed PASC. Blood analysis showed that the main differences observed in humoral, viral, and biological biomarkers were associated with the initial COVID-19 severity, rather than being specifically linked to PASC. However, patients with PASC displayed altered CD4+ and CD8+ memory T cell subsets, with higher cytokine-secreting cells and increased terminally differentiated CD45RA+ effector memory T cells (TEMRA). Elevated SARS-CoV-2-specific T cells responsive to nucleocapsid/membrane proteins with a TEMRA phenotype were also observed. A random forest model identified these features and initial symptom duration as top variables discriminating PASC, achieving over 80% classification accuracy.

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来源期刊
CiteScore
8.30
自引率
3.70%
发文量
224
审稿时长
2 months
期刊介绍: The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.
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