血浆中微生物来源的无细胞RNA的修饰可区分结直肠癌样本

IF 33.1 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Nature biotechnology Pub Date : 2025-07-08 DOI:10.1038/s41587-025-02731-8

Cheng-Wei Ju, Ruitu Lyu, Han Li, Jiangbo Wei, Alberto J. Parra Vitela, Urszula Dougherty, Akushika Kwesi, Alexander Luna, Xuanhao Zhu, Shenghai Shen, Yunzheng Liu, Liangliang Wang, Xiaolong Cui, Yuzhi Xu, Bochen Jiang, Yiyi Ji, Peng Xia, Diana C. West-Szymanski, Chenxi Sun, Yuhao Zhong, Chang Ye, Angelica Moran, Christopher Lehmann, Eric Pamer, Wei Zhang, Marc Bissonnette, Li-Sheng Zhang, Chuan He

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引用次数: 0

摘要

血浆循环无细胞RNA （cfRNA）是一种很有前途的癌症检测方法。我们报道了低输入多重甲基化测序，这是一种分析cfRNA修饰模式的方法，能够检测来自人类基因组和微生物组的多种转移rna和小非编码rna。微生物组衍生的cfRNA的RNA修饰模式准确地反映了宿主微生物群的活性，并具有早期检测结直肠癌的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples

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Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples

Circulating cell-free RNA (cfRNA) in plasma represents a promising avenue for cancer detection. We report low-input multiple methylation sequencing, a method for profiling modification patterns in cfRNA, enabling the detection of diverse transfer RNAs and small noncoding RNAs derived from both the human genome and the microbiome. RNA modification patterns in microbiome-derived cfRNA accurately reflect host microbiota activity and hold potential for the early detection of colorectal cancer.

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来源期刊

Nature biotechnology 工程技术-生物工程与应用微生物

CiteScore

63.00

自引率

1.70%

发文量

382

审稿时长

3 months

期刊介绍： Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.