有癌症病史的患者因退行性和创伤性病理进行脊柱手术的发生率:1997年至2020年芬兰一项基于全国登记的研究

IF 2.5 2区 医学 Q1 ORTHOPEDICS
Leevi A Toivonen, Ville Ponkilainen, Jussi P Repo, Ville M Mattila
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引用次数: 0

摘要

背景和目的:癌症幸存者的数量有所增加。尽管脊柱手术率在普通人群中翻了一番,但在癌症人群中还没有得到充分的研究。我们的目的是确定既往癌症患者退行性和创伤性病理脊柱手术的发生率。我们的第二个目的是确定脊柱手术后潜在的原发性癌症诊断和生存率。方法:数据来自3个全国性登记:芬兰癌症登记、芬兰卫生保健护理登记和芬兰死因登记。脊柱手术采用诊断和程序代码进行识别,排除肿瘤手术。发病率按每10万居民计算,并根据年龄和性别进行调整。在第一次脊柱手术时计算Kaplan-Meier生存估计(95%置信区间[CI])。结果:10,280例患者接受手术12,425例,平均年龄70岁;53%是女性。退行性病变占手术的74%,其次是椎间盘病变(20%)和创伤(6%)。从1997年到2019年,脊柱手术的发生率从每10万人年3.7例增加到15.1例(300%)。增加主要发生在退行性脊柱手术中(420%),而椎间盘和创伤手术则暂时稳定。最常见的先前诊断癌症是乳腺癌(24%)和前列腺癌(22%)。脊柱手术后1年全因生存率为94% (CI 94-95), 15年癌症特异性生存率为90% (CI 0.89-0.91)。结论:我们发现,在1997年至2020年间,有癌症病史的患者中,与癌症无关的脊柱手术增加了300%。1年生存率保持良好(94% [CI 0.89-0.91])。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Incidence of spine surgery for degenerative and traumatic pathologies in patients with a history of cancer: a nationwide register-based study between 1997 and 2020 from Finland.

Background and purpose:  The number of cancer survivors has increased. Although spine surgery rates have multiplied in the general population, they are understudied in cancer populations. We aimed to determine the incidence rates of spinal surgery for degenerative and traumatic pathologies in patients with prior cancer. Our secondary aim was to define the underlying primary cancer diagnoses and survival rates after spinal procedures.

Methods:  Data was combined from 3 nationwide registers: the Finnish Cancer Register, Finnish Care Register for Health Care, and Finnish Cause of Death Register. Spine surgeries were identified using diagnosis and procedural codes, and tumor surgeries were excluded. Incidence rates were calculated per 100,000 inhabitants and adjusted for age and sex. Kaplan-Meier survival estimates (with 95% confidence intervals [CI]) were calculated per the first spine surgery.

Results:  10,280 patients underwent 12,425 surgeries, with a mean age of 70 years; 53% were women. Degenerative pathologies accounted for 74% of the surgeries, followed by disc pathologies (20%) and trauma (6%). The incidence of spine surgeries increased from 3.7 to 15.1 per 100,000 person-years (300%) between 1997 and 2019. The increase mostly occurred in degenerative spine procedures (420%), whereas disc and trauma surgeries were temporally stable. The most common previously diagnosed cancers were breast (24%) and prostate (22%) cancers. All-cause survival after spine surgery was 94% (CI 94-95) at 1 year, and cancer-specific survival was 90% (CI 0.89-0.91) at 15 years.

Conclusion:  We showed a 300% increase in spine surgeries unrelated to cancer in patients with a history of cancer between 1997 and 2020. Survival rates remained favorable (94% [CI 0.89-0.91] at 1 year).

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来源期刊
Acta Orthopaedica
Acta Orthopaedica 医学-整形外科
CiteScore
6.40
自引率
8.10%
发文量
105
审稿时长
4-8 weeks
期刊介绍: Acta Orthopaedica (previously Acta Orthopaedica Scandinavica) presents original articles of basic research interest, as well as clinical studies in the field of orthopedics and related sub disciplines. Ever since the journal was founded in 1930, by a group of Scandinavian orthopedic surgeons, the journal has been published for an international audience. Acta Orthopaedica is owned by the Nordic Orthopaedic Federation and is the official publication of this federation.
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