{"title":"番茄红素调节甘油磷脂代谢和促进n -酰基乙醇胺的产生以减轻肥胖","authors":"Jingyu Lu, Liyang Zhou, Chang Liu, He Qian","doi":"10.1111/1750-3841.70373","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <p>Obesity is often associated with dysregulated glycerophospholipid metabolism. Lycopene is known for its anti-obesity properties. However, the mechanism by which lycopene affects glycerophospholipid metabolism in obesity remains unclear. Here, a lycopene small intestinal sustained-release system (SR-Ly) was designed. Subsequently, SR-Ly was used to interfere with fatty liver caused by high-fat diet in mice. SR-Ly exhibited high encapsulation efficiency, stability, and sustained release, significantly enhancing lycopene's bioavailability. Moreover, treatment with SR-Ly resulted in reduced body weight gain in obese mice. Lipidomic analysis revealed significant modulation of glycerophospholipid pathways with lycopene increasing beneficial glycerophospholipids. Correlation-based analysis further suggested that lycopene may promote the conversion of N-acyl phosphatidylethanolamine to N-acylethanolamines (NAE), highlighting a possible metabolic route of interest. Structural equation modeling supported the association between lycopene intervention and improved glycerophospholipid metabolism. Additionally, compared to lipid oxidation, it was verified at both the gene and protein levels that lycopene has a greater positive effect on lipid synthesis in the mouse liver. Hence, SR-Ly is a promising therapeutic approach for fatty liver, effectively targeting glycerophospholipid metabolism.</p>\n </section>\n \n <section>\n \n <h3> Practical Application</h3>\n \n <p>SR-Ly enhanced lycopene's stability, bioavailability, and sustained release. SR-Ly reduced body weight gain and modulated glycerophospholipid metabolism. Lycopene promoted N-acyl phosphatidylethanolamine conversion to N-Acylethanolamines. Lycopene improved glycerophospholipid metabolism, favoring lipid synthesis over oxidation.</p>\n </section>\n </div>","PeriodicalId":193,"journal":{"name":"Journal of Food Science","volume":"90 7","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lycopene Modulates Glycerophospholipid Metabolism and Promotes N-Acylethanolamine Production to Alleviate Obesity\",\"authors\":\"Jingyu Lu, Liyang Zhou, Chang Liu, He Qian\",\"doi\":\"10.1111/1750-3841.70373\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <p>Obesity is often associated with dysregulated glycerophospholipid metabolism. Lycopene is known for its anti-obesity properties. However, the mechanism by which lycopene affects glycerophospholipid metabolism in obesity remains unclear. Here, a lycopene small intestinal sustained-release system (SR-Ly) was designed. Subsequently, SR-Ly was used to interfere with fatty liver caused by high-fat diet in mice. SR-Ly exhibited high encapsulation efficiency, stability, and sustained release, significantly enhancing lycopene's bioavailability. Moreover, treatment with SR-Ly resulted in reduced body weight gain in obese mice. Lipidomic analysis revealed significant modulation of glycerophospholipid pathways with lycopene increasing beneficial glycerophospholipids. Correlation-based analysis further suggested that lycopene may promote the conversion of N-acyl phosphatidylethanolamine to N-acylethanolamines (NAE), highlighting a possible metabolic route of interest. Structural equation modeling supported the association between lycopene intervention and improved glycerophospholipid metabolism. Additionally, compared to lipid oxidation, it was verified at both the gene and protein levels that lycopene has a greater positive effect on lipid synthesis in the mouse liver. Hence, SR-Ly is a promising therapeutic approach for fatty liver, effectively targeting glycerophospholipid metabolism.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Practical Application</h3>\\n \\n <p>SR-Ly enhanced lycopene's stability, bioavailability, and sustained release. SR-Ly reduced body weight gain and modulated glycerophospholipid metabolism. Lycopene promoted N-acyl phosphatidylethanolamine conversion to N-Acylethanolamines. Lycopene improved glycerophospholipid metabolism, favoring lipid synthesis over oxidation.</p>\\n </section>\\n </div>\",\"PeriodicalId\":193,\"journal\":{\"name\":\"Journal of Food Science\",\"volume\":\"90 7\",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Food Science\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/1750-3841.70373\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Food Science","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/1750-3841.70373","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Lycopene Modulates Glycerophospholipid Metabolism and Promotes N-Acylethanolamine Production to Alleviate Obesity
Obesity is often associated with dysregulated glycerophospholipid metabolism. Lycopene is known for its anti-obesity properties. However, the mechanism by which lycopene affects glycerophospholipid metabolism in obesity remains unclear. Here, a lycopene small intestinal sustained-release system (SR-Ly) was designed. Subsequently, SR-Ly was used to interfere with fatty liver caused by high-fat diet in mice. SR-Ly exhibited high encapsulation efficiency, stability, and sustained release, significantly enhancing lycopene's bioavailability. Moreover, treatment with SR-Ly resulted in reduced body weight gain in obese mice. Lipidomic analysis revealed significant modulation of glycerophospholipid pathways with lycopene increasing beneficial glycerophospholipids. Correlation-based analysis further suggested that lycopene may promote the conversion of N-acyl phosphatidylethanolamine to N-acylethanolamines (NAE), highlighting a possible metabolic route of interest. Structural equation modeling supported the association between lycopene intervention and improved glycerophospholipid metabolism. Additionally, compared to lipid oxidation, it was verified at both the gene and protein levels that lycopene has a greater positive effect on lipid synthesis in the mouse liver. Hence, SR-Ly is a promising therapeutic approach for fatty liver, effectively targeting glycerophospholipid metabolism.
Practical Application
SR-Ly enhanced lycopene's stability, bioavailability, and sustained release. SR-Ly reduced body weight gain and modulated glycerophospholipid metabolism. Lycopene promoted N-acyl phosphatidylethanolamine conversion to N-Acylethanolamines. Lycopene improved glycerophospholipid metabolism, favoring lipid synthesis over oxidation.
期刊介绍：
The goal of the Journal of Food Science is to offer scientists, researchers, and other food professionals the opportunity to share knowledge of scientific advancements in the myriad disciplines affecting their work, through a respected peer-reviewed publication. The Journal of Food Science serves as an international forum for vital research and developments in food science.
The range of topics covered in the journal include:
-Concise Reviews and Hypotheses in Food Science
-New Horizons in Food Research
-Integrated Food Science
-Food Chemistry
-Food Engineering, Materials Science, and Nanotechnology
-Food Microbiology and Safety
-Sensory and Consumer Sciences
-Health, Nutrition, and Food
-Toxicology and Chemical Food Safety
The Journal of Food Science publishes peer-reviewed articles that cover all aspects of food science, including safety and nutrition. Reviews should be 15 to 50 typewritten pages (including tables, figures, and references), should provide in-depth coverage of a narrowly defined topic, and should embody careful evaluation (weaknesses, strengths, explanation of discrepancies in results among similar studies) of all pertinent studies, so that insightful interpretations and conclusions can be presented. Hypothesis papers are especially appropriate in pioneering areas of research or important areas that are afflicted by scientific controversy.
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