细胞外囊泡作为肿瘤的生物标志物和药物传递系统

IF 14.6 1区医学 Q1 PHARMACOLOGY & PHARMACY

Acta Pharmaceutica Sinica. B Pub Date : 2025-07-01 DOI:10.1016/j.apsb.2025.04.033

Xue Wang , Wenjing Chen , Wei Zeng , Kuanhan Feng , Yu Zheng , Ping Wang , Fucai Chen , Wen Zhang , Liuqing Di , Ruoning Wang

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引用次数: 0

摘要

细胞外囊泡（EVs）对促进细胞间通讯、促进细胞迁移和协调免疫反应至关重要。最近，电动汽车可以诊断和治疗肿瘤。ev可以作为生物标志物进行测量，以提供有关疾病类型和治疗效果的信息。此外，电动汽车具有较低的免疫原性和较好的生物相容性，是化学药品和基因药物的天然载体。本文综述了电动汽车的分子组成、生物发生和分离方法。我们还强调了不同来源的ev作为生物标志物和药物传递系统在肿瘤治疗中的重要作用。最后，我们深入研究了电动汽车如何在逆转免疫抑制微环境中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Extracellular vesicles as biomarkers and drug delivery systems for tumor

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Extracellular vesicles as biomarkers and drug delivery systems for tumor

Extracellular vesicles (EVs) are crucial for facilitating intercellular communication, promoting cell migration, and orchestrating the immune response. Recently, EVs can diagnose and treat tumors. EVs can be measured as biomarkers to provide information about the type of disease and therapeutic efficacy. Furthermore, EVs with lower immunogenicity and better biocompatibility are natural carriers of chemicals and gene drugs. Herein, we review the molecular composition, biogenesis, and separation methods of EVs. We also highlight the important role of EVs from different origins as biomarkers and drug delivery systems in tumor therapy. Finally, we provide deep insights into how EVs play a role in reversing the immunosuppressive microenvironment.

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来源期刊

Acta Pharmaceutica Sinica. B Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics

CiteScore

22.40

自引率

5.50%

发文量

1051

审稿时长

19 weeks

期刊介绍： The Journal of the Institute of Materia Medica, Chinese Academy of Medical Sciences, and the Chinese Pharmaceutical Association oversees the peer review process for Acta Pharmaceutica Sinica. B (APSB). Published monthly in English, APSB is dedicated to disseminating significant original research articles, rapid communications, and high-quality reviews that highlight recent advances across various pharmaceutical sciences domains. These encompass pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis, and pharmacokinetics. A part of the Acta Pharmaceutica Sinica series, established in 1953 and indexed in prominent databases like Chemical Abstracts, Index Medicus, SciFinder Scholar, Biological Abstracts, International Pharmaceutical Abstracts, Cambridge Scientific Abstracts, and Current Bibliography on Science and Technology, APSB is sponsored by the Institute of Materia Medica, Chinese Academy of Medical Sciences, and the Chinese Pharmaceutical Association. Its production and hosting are facilitated by Elsevier B.V. This collaborative effort ensures APSB's commitment to delivering valuable contributions to the pharmaceutical sciences community.