{"title":"更多癌症风险评估的欺诈性历史:美国国家科学院原子辐射生物效应(BEAR) I遗传学小组使用伪造的数据大大夸大了遗传/癌症风险。","authors":"Edward J. Calabrese , Paul B. Selby","doi":"10.1016/j.cbi.2025.111640","DOIUrl":null,"url":null,"abstract":"<div><div>This paper reports that data used by the US National Academy of Sciences (NAS) Biological Effects of Atomic Radiation (BEAR) I Genetics Panel (1956) to estimate risks of hereditary damage in the US population were falsified, greatly exaggerating the risks. These risk estimates were mostly based on the first of many mouse specific-locus experiments of William and Liane Russell, Oak Ridge National Laboratory, which were determined in 1996 to be erroneous by a US Department of Energy (DOE) investigation of scientific misconduct. The basis of the falsification is that William Russell removed data on a large mutation cluster from the control group resulting in a falsely elevated estimate of the induced frequency of radiation-induced gene mutations. While DOE subsequently compelled the Russells to correct the record, these corrections were never retrospectively applied to the Genetics Panel (1956) report, which used the falsified Russell data. Thus, no corrections have been made by the NAS or regulatory agencies, such as the EPA, whose national risk assessment policies/practices for cancer risk assessment were significantly corrupted and overstated by these errors. Based on the discovery reported herein that the Genetics Panel's policy recommendations considerably overestimated hereditary risks based upon Russell-inspired falsified publication, it seems imperative that the Genetics Panel report (1956) published in <em>Science</em> be retracted due to inherent falsification-based inaccuracies that continue to impact governmental regulatory agencies, such as the EPA, and the global community that often rely upon the US NAS and regulatory agencies for guidance, as well as the broader scientific community and general public.</div></div>","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"419 ","pages":"Article 111640"},"PeriodicalIF":5.4000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"More fraudulent history of cancer risk assessment: The US National Academy of Sciences Biological Effects of Atomic Radiation (BEAR) I Genetics Panel used falsified data greatly exaggerating hereditary/cancer risks\",\"authors\":\"Edward J. Calabrese , Paul B. Selby\",\"doi\":\"10.1016/j.cbi.2025.111640\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This paper reports that data used by the US National Academy of Sciences (NAS) Biological Effects of Atomic Radiation (BEAR) I Genetics Panel (1956) to estimate risks of hereditary damage in the US population were falsified, greatly exaggerating the risks. These risk estimates were mostly based on the first of many mouse specific-locus experiments of William and Liane Russell, Oak Ridge National Laboratory, which were determined in 1996 to be erroneous by a US Department of Energy (DOE) investigation of scientific misconduct. The basis of the falsification is that William Russell removed data on a large mutation cluster from the control group resulting in a falsely elevated estimate of the induced frequency of radiation-induced gene mutations. While DOE subsequently compelled the Russells to correct the record, these corrections were never retrospectively applied to the Genetics Panel (1956) report, which used the falsified Russell data. Thus, no corrections have been made by the NAS or regulatory agencies, such as the EPA, whose national risk assessment policies/practices for cancer risk assessment were significantly corrupted and overstated by these errors. Based on the discovery reported herein that the Genetics Panel's policy recommendations considerably overestimated hereditary risks based upon Russell-inspired falsified publication, it seems imperative that the Genetics Panel report (1956) published in <em>Science</em> be retracted due to inherent falsification-based inaccuracies that continue to impact governmental regulatory agencies, such as the EPA, and the global community that often rely upon the US NAS and regulatory agencies for guidance, as well as the broader scientific community and general public.</div></div>\",\"PeriodicalId\":274,\"journal\":{\"name\":\"Chemico-Biological Interactions\",\"volume\":\"419 \",\"pages\":\"Article 111640\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemico-Biological Interactions\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0009279725002704\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemico-Biological Interactions","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0009279725002704","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
More fraudulent history of cancer risk assessment: The US National Academy of Sciences Biological Effects of Atomic Radiation (BEAR) I Genetics Panel used falsified data greatly exaggerating hereditary/cancer risks
This paper reports that data used by the US National Academy of Sciences (NAS) Biological Effects of Atomic Radiation (BEAR) I Genetics Panel (1956) to estimate risks of hereditary damage in the US population were falsified, greatly exaggerating the risks. These risk estimates were mostly based on the first of many mouse specific-locus experiments of William and Liane Russell, Oak Ridge National Laboratory, which were determined in 1996 to be erroneous by a US Department of Energy (DOE) investigation of scientific misconduct. The basis of the falsification is that William Russell removed data on a large mutation cluster from the control group resulting in a falsely elevated estimate of the induced frequency of radiation-induced gene mutations. While DOE subsequently compelled the Russells to correct the record, these corrections were never retrospectively applied to the Genetics Panel (1956) report, which used the falsified Russell data. Thus, no corrections have been made by the NAS or regulatory agencies, such as the EPA, whose national risk assessment policies/practices for cancer risk assessment were significantly corrupted and overstated by these errors. Based on the discovery reported herein that the Genetics Panel's policy recommendations considerably overestimated hereditary risks based upon Russell-inspired falsified publication, it seems imperative that the Genetics Panel report (1956) published in Science be retracted due to inherent falsification-based inaccuracies that continue to impact governmental regulatory agencies, such as the EPA, and the global community that often rely upon the US NAS and regulatory agencies for guidance, as well as the broader scientific community and general public.
期刊介绍:
Chemico-Biological Interactions publishes research reports and review articles that examine the molecular, cellular, and/or biochemical basis of toxicologically relevant outcomes. Special emphasis is placed on toxicological mechanisms associated with interactions between chemicals and biological systems. Outcomes may include all traditional endpoints caused by synthetic or naturally occurring chemicals, both in vivo and in vitro. Endpoints of interest include, but are not limited to carcinogenesis, mutagenesis, respiratory toxicology, neurotoxicology, reproductive and developmental toxicology, and immunotoxicology.