更多癌症风险评估的欺诈性历史:美国国家科学院原子辐射生物效应(BEAR) I遗传学小组使用伪造的数据大大夸大了遗传/癌症风险。

IF 5.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Edward J. Calabrese , Paul B. Selby
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引用次数: 0

摘要

本文报告了美国国家科学院(NAS)原子辐射生物效应(BEAR) I遗传学小组(1956)用于估计美国人口遗传损害风险的数据是伪造的,大大夸大了风险。这一风险估计是基于橡树岭国家实验室的William和Liane Russell的许多小鼠特定位点实验中的第一个,这些实验在1996年被美国能源部(DOE)对科学不端行为的调查确定为错误。伪造的基础是William Russell从对照组中删除了一个大突变簇的数据,从而错误地提高了辐射诱导基因突变的诱导频率估计。虽然美国能源部随后迫使罗素更正记录,但这些更正从未追溯应用于遗传学小组(1956)的报告,该报告使用了伪造的罗素数据。因此,NAS或监管机构(如EPA)没有做出任何纠正,它们的国家风险评估政策/癌症风险评估实践因这些错误而受到严重破坏和夸大。根据本文报告的发现,遗传学小组的政策建议在很大程度上高估了基于罗素启发的伪造出版物的遗传风险,似乎有必要撤回遗传学小组发表在《科学》杂志上的报告(1956年),因为固有的基于伪造的不准确性将继续影响政府监管机构,如EPA,以及经常依赖美国NAS和监管机构指导的全球社区。以及更广泛的科学界和公众。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
More fraudulent history of cancer risk assessment: The US National Academy of Sciences Biological Effects of Atomic Radiation (BEAR) I Genetics Panel used falsified data greatly exaggerating hereditary/cancer risks
This paper reports that data used by the US National Academy of Sciences (NAS) Biological Effects of Atomic Radiation (BEAR) I Genetics Panel (1956) to estimate risks of hereditary damage in the US population were falsified, greatly exaggerating the risks. These risk estimates were mostly based on the first of many mouse specific-locus experiments of William and Liane Russell, Oak Ridge National Laboratory, which were determined in 1996 to be erroneous by a US Department of Energy (DOE) investigation of scientific misconduct. The basis of the falsification is that William Russell removed data on a large mutation cluster from the control group resulting in a falsely elevated estimate of the induced frequency of radiation-induced gene mutations. While DOE subsequently compelled the Russells to correct the record, these corrections were never retrospectively applied to the Genetics Panel (1956) report, which used the falsified Russell data. Thus, no corrections have been made by the NAS or regulatory agencies, such as the EPA, whose national risk assessment policies/practices for cancer risk assessment were significantly corrupted and overstated by these errors. Based on the discovery reported herein that the Genetics Panel's policy recommendations considerably overestimated hereditary risks based upon Russell-inspired falsified publication, it seems imperative that the Genetics Panel report (1956) published in Science be retracted due to inherent falsification-based inaccuracies that continue to impact governmental regulatory agencies, such as the EPA, and the global community that often rely upon the US NAS and regulatory agencies for guidance, as well as the broader scientific community and general public.
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来源期刊
CiteScore
7.70
自引率
3.90%
发文量
410
审稿时长
36 days
期刊介绍: Chemico-Biological Interactions publishes research reports and review articles that examine the molecular, cellular, and/or biochemical basis of toxicologically relevant outcomes. Special emphasis is placed on toxicological mechanisms associated with interactions between chemicals and biological systems. Outcomes may include all traditional endpoints caused by synthetic or naturally occurring chemicals, both in vivo and in vitro. Endpoints of interest include, but are not limited to carcinogenesis, mutagenesis, respiratory toxicology, neurotoxicology, reproductive and developmental toxicology, and immunotoxicology.
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