{"title":"健康对照与进行性核上性麻痹患者区域T1/ t2加权比值指数的差异","authors":"Miho Ota, Noriko Sato, Yuji Takahashi, Yoko Shigemoto, Yukio Kimura, Hiroyuki Maki, Tomoki Imokawa, Risa Kagaya, Hiroshi Matsuda","doi":"10.1111/psyg.70069","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Progressive supranuclear palsy (PSP) is a four-repeat tauopathy, and the differentiation of PSP from other neurodegenerative disorders is a common clinical problem. We applied a T1-/T2-weighted ratio imaging technique based on standard clinical MRI to investigate PSP-related changes in neuroimaging data.</p><p><strong>Method: </strong>Twenty patients with PSP and 34 healthy participants underwent an examination to obtain T1- and T2-weighted images at our hospital. We retrospectively computed each subject's T1/T2-weighted ratio index to use as a proxy for the brain's myelin content, and we analyzed the differences in the index values between the PSP and control groups.</p><p><strong>Results: </strong>Our analysis revealed the precise differences in the T1/T2-weighted ratio index between the PSP and control groups and demonstrated that the patients with PSP showed significant reductions of the T1/T2-weighted ratio index in the midbrain, posterior commissure, caudate, thalamus, and bilateral insulae compared to the healthy controls.</p><p><strong>Conclusions: </strong>These results show that the T1/T2-weighted ratio approach is useful to distinguish patients with PSP from healthy subjects.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":"25 4","pages":"e70069"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Differences in the Regional T1/T2-Weighted Ratio Index Between Healthy Controls and Patients With Progressive Supranuclear Palsy.\",\"authors\":\"Miho Ota, Noriko Sato, Yuji Takahashi, Yoko Shigemoto, Yukio Kimura, Hiroyuki Maki, Tomoki Imokawa, Risa Kagaya, Hiroshi Matsuda\",\"doi\":\"10.1111/psyg.70069\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Progressive supranuclear palsy (PSP) is a four-repeat tauopathy, and the differentiation of PSP from other neurodegenerative disorders is a common clinical problem. We applied a T1-/T2-weighted ratio imaging technique based on standard clinical MRI to investigate PSP-related changes in neuroimaging data.</p><p><strong>Method: </strong>Twenty patients with PSP and 34 healthy participants underwent an examination to obtain T1- and T2-weighted images at our hospital. We retrospectively computed each subject's T1/T2-weighted ratio index to use as a proxy for the brain's myelin content, and we analyzed the differences in the index values between the PSP and control groups.</p><p><strong>Results: </strong>Our analysis revealed the precise differences in the T1/T2-weighted ratio index between the PSP and control groups and demonstrated that the patients with PSP showed significant reductions of the T1/T2-weighted ratio index in the midbrain, posterior commissure, caudate, thalamus, and bilateral insulae compared to the healthy controls.</p><p><strong>Conclusions: </strong>These results show that the T1/T2-weighted ratio approach is useful to distinguish patients with PSP from healthy subjects.</p>\",\"PeriodicalId\":74597,\"journal\":{\"name\":\"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society\",\"volume\":\"25 4\",\"pages\":\"e70069\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/psyg.70069\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/psyg.70069","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Differences in the Regional T1/T2-Weighted Ratio Index Between Healthy Controls and Patients With Progressive Supranuclear Palsy.
Background: Progressive supranuclear palsy (PSP) is a four-repeat tauopathy, and the differentiation of PSP from other neurodegenerative disorders is a common clinical problem. We applied a T1-/T2-weighted ratio imaging technique based on standard clinical MRI to investigate PSP-related changes in neuroimaging data.
Method: Twenty patients with PSP and 34 healthy participants underwent an examination to obtain T1- and T2-weighted images at our hospital. We retrospectively computed each subject's T1/T2-weighted ratio index to use as a proxy for the brain's myelin content, and we analyzed the differences in the index values between the PSP and control groups.
Results: Our analysis revealed the precise differences in the T1/T2-weighted ratio index between the PSP and control groups and demonstrated that the patients with PSP showed significant reductions of the T1/T2-weighted ratio index in the midbrain, posterior commissure, caudate, thalamus, and bilateral insulae compared to the healthy controls.
Conclusions: These results show that the T1/T2-weighted ratio approach is useful to distinguish patients with PSP from healthy subjects.
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