{"title":"具有同态性染色体的刺蛙性别连锁转录本的性别偏倚表达。","authors":"Yu Xiao, Yun Xia, Xiaomao Zeng","doi":"10.1186/s12864-025-11846-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The accumulation of sexually antagonistic mutations on chromosomes has been favored in driving the evolution of sex chromosomes. However, empirical evidence has been limited to species with heteromorphic sex chromosomes, where the patterns of gene expression on sex chromosomes differ drastically from those on autosomes. It is little known if the sexualization of gene expression would have started on homomorphic sex chromosomes.</p><p><strong>Results: </strong>To investigate the evolutionary patterns of sex-biased expression, we examined four species of spiny frogs, using high-throughput RNA sequencing for gonads and sex-specific tissues. We find little support for both the enrichment of sex-linked genes and the excess of sex-linked gene expression. Additionally, there is no evidence supporting for sex-biased gene expression near the candidate sex-determining locus. We find no significant accumulation of sex-biased genes on sex chromosomes. Further, the homomorphic sex chromosomes do not show evidence of a faster rate of evolution.</p><p><strong>Conclusions: </strong>The sexualization of sex chromosomes in species with homomorphic sex chromosomes may not be as indispensable as hypothesized.</p>","PeriodicalId":9030,"journal":{"name":"BMC Genomics","volume":"26 1","pages":"636"},"PeriodicalIF":3.7000,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229019/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sex-biased expression of sex-linked transcripts in spiny frogs with homomorphic sex chromosomes.\",\"authors\":\"Yu Xiao, Yun Xia, Xiaomao Zeng\",\"doi\":\"10.1186/s12864-025-11846-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The accumulation of sexually antagonistic mutations on chromosomes has been favored in driving the evolution of sex chromosomes. However, empirical evidence has been limited to species with heteromorphic sex chromosomes, where the patterns of gene expression on sex chromosomes differ drastically from those on autosomes. It is little known if the sexualization of gene expression would have started on homomorphic sex chromosomes.</p><p><strong>Results: </strong>To investigate the evolutionary patterns of sex-biased expression, we examined four species of spiny frogs, using high-throughput RNA sequencing for gonads and sex-specific tissues. We find little support for both the enrichment of sex-linked genes and the excess of sex-linked gene expression. Additionally, there is no evidence supporting for sex-biased gene expression near the candidate sex-determining locus. We find no significant accumulation of sex-biased genes on sex chromosomes. Further, the homomorphic sex chromosomes do not show evidence of a faster rate of evolution.</p><p><strong>Conclusions: </strong>The sexualization of sex chromosomes in species with homomorphic sex chromosomes may not be as indispensable as hypothesized.</p>\",\"PeriodicalId\":9030,\"journal\":{\"name\":\"BMC Genomics\",\"volume\":\"26 1\",\"pages\":\"636\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-07-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229019/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Genomics\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1186/s12864-025-11846-w\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Genomics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1186/s12864-025-11846-w","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Sex-biased expression of sex-linked transcripts in spiny frogs with homomorphic sex chromosomes.
Background: The accumulation of sexually antagonistic mutations on chromosomes has been favored in driving the evolution of sex chromosomes. However, empirical evidence has been limited to species with heteromorphic sex chromosomes, where the patterns of gene expression on sex chromosomes differ drastically from those on autosomes. It is little known if the sexualization of gene expression would have started on homomorphic sex chromosomes.
Results: To investigate the evolutionary patterns of sex-biased expression, we examined four species of spiny frogs, using high-throughput RNA sequencing for gonads and sex-specific tissues. We find little support for both the enrichment of sex-linked genes and the excess of sex-linked gene expression. Additionally, there is no evidence supporting for sex-biased gene expression near the candidate sex-determining locus. We find no significant accumulation of sex-biased genes on sex chromosomes. Further, the homomorphic sex chromosomes do not show evidence of a faster rate of evolution.
Conclusions: The sexualization of sex chromosomes in species with homomorphic sex chromosomes may not be as indispensable as hypothesized.
期刊介绍：
BMC Genomics is an open access, peer-reviewed journal that considers articles on all aspects of genome-scale analysis, functional genomics, and proteomics.
BMC Genomics is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We offer an efficient, fair and friendly peer review service, and are committed to publishing all sound science, provided that there is some advance in knowledge presented by the work.
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