Optimization approach for complete magnetic hyperthermia model considering open magnetic field device

Magnetic hyperthermia damages malignant tissue by the temperature elevation to a specific value, which is one of most popular treatment methods due to its safety with respect to other traditional ways. Magnetic nanoparticles (MNPs) with nanoscale size release the heat for bio-tissue according to Rosensweig’ theory when subjected to an alternating magnetic field. Previous reports mainly focused on the magnetic field in a relatively enclosed space, which however generally has some limitation on the placement of larger volume target and can lead to the inhomogeneous distribution due to the increase of internal space. This study establishes an open magnetic field device for magnetic hyperthermia, which is evaluated by the treatment effect of a simple rat model. Further, this device is also optimized by considering the radius of planar coil and by introducing a PID controller with adjusted parameters. After using finite element method for corresponding partial differential equations, the magnetic field profile for the proposed planar coil obtained is sequentially coupled with the temperature field distribution of biological tissue. The results demonstrate that the planar coil with more rings can result in a better scenario for magnetic hyperthermia with respect to less rings case to some extent. In addition, the proposed PID controller can be used to improve the thermal damage of malignant tissue by decreasing both the setting time and the overshoot for spatiotemporal temperature during therapy.