建立血浆p-Tau217群体特异性截止点的建模方法。

IF 4.3 Q2 BUSINESS
Tau Ming Liew
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引用次数: 0

摘要

血浆pTau-217有望检测阿尔茨海默病,但需要针对特定人群的临界值才能有效使用。传统的截止点确定依赖于侵入性或昂贵的黄金标准,限制了可扩展性。本研究评估了有限混合模型(FMM)在没有金标准的情况下建立临界值。FMM应用于1039名ADNI参与者中得出Lumipulse血浆p-Tau217和p-Tau217/ a - β42比值的截止值,并在淀粉样蛋白PET数据的子集中进行验证(n = 711)。此外,还进行了模拟以确定可靠的FMM估计的最小样本量。结果显示,fmm衍生的截止值有效地将参与者分为脑淀粉样蛋白阴性、阳性和不确定组,比例不确定
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A modelling approach to derive population-specific cutoff for plasma p-Tau217.

Plasma pTau-217 shows promise for detecting Alzheimer's disease, but needs population-specific cutoffs for effective use. Conventional cutoff determination relies on invasive or costly gold-standards, limiting scalability. This study evaluated Finite Mixture Modelling (FMM) for establishing cutoffs without gold-standards. FMM was applied to derive cutoffs for Lumipulse plasma p-Tau217 and p-Tau217/Aβ42 ratio among 1039 ADNI participants, with validation conducted in a subset with amyloid PET data (n = 711). Additionally, simulations were conducted to determine the minimum sample size for reliable FMM estimation. The results showed that FMM-derived cutoffs effectively classified participants into brain amyloid-negative, -positive, and -indeterminate groups, with an indeterminate proportion <20 %, negative and positive predictive values near or above 90 %, and with p-Tau217/Aβ42 outperforming p-Tau217. These FMM-derived cutoffs demonstrated test performance that surpassed several previously-established cutoffs, including the recent FDA-approved cutoff. At least 900 samples were needed for reliable cutoff estimation. In conclusion, this study demonstrated the effectiveness of a modelling approach for estimating plasma p-Tau217 cutoffs without reliance on gold-standards. This approach simplifies the determinating of population-specific cutoffs and facilitates adoption of plasma p-Tau217 in communities lacking access to gold-standards, including some LMICs.

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来源期刊
The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
自引率
0.00%
发文量
0
期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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