Md Mahmudul Hasan, Shah Md Wasin, Mishu Rahman, Eva Azme, Md Saqline Mostaq, Md Mahedi Hasan Nahid, Nor Mohammad, Farjana Afrin Tanjum, Md Anamul Haque, Md Ashiq Mahmud, Mohammad Nurul Amin
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This research seeks to illustrate the mechanisms and clinical findings of natural products against breast cancer treatment.</p><p><strong>Methodology: </strong>Required data for this review article was retrieved employing several readily obtainable search databases, including Web of Science<sup>®</sup> (Thomson Reuters, USA), PubMed<sup>®</sup> (U.S. National Library of Medicine, USA), and SciVerse Scopus<sup>®</sup> (Elsevier Properties S.A., USA), taking into consideration certain search terms like \"breast cancer,\" \"natural products against breast cancer,\" and \"Clinically proven natural products in the treatment of breast cancer\" and so on.</p><p><strong>Results: </strong>Several natural products, namely Omega-3 fatty acids, dietary isothiocyanates, curcumin, green tea, flaxseed, limonene, and others, were found to modulate crucial pathways in breast cancer cells. These substances suppressed angiogenesis by downregulating the vascular endothelial growth factor (VEGF), promoted apoptosis by activating caspase enzymes, and prevented cell proliferation by controlling cyclin-dependent kinases. Clinical studies demonstrated improved outcomes in patients receiving these natural products with standard treatment procedures.</p><p><strong>Discussion: </strong>The findings underscore the multifaceted functions of natural products in breast cancer therapy, highlighting their potential to increase the efficacy of conventional treatments while reducing adverse effects. Further exploration of synergistic actions and optimal dosages is needed.</p><p><strong>Conclusion: </strong>Clinically proven natural products represent a potential avenue for breast cancer treatment with their mechanistic insights that facilitate their incorporation into treatment regimens. 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This research seeks to illustrate the mechanisms and clinical findings of natural products against breast cancer treatment.</p><p><strong>Methodology: </strong>Required data for this review article was retrieved employing several readily obtainable search databases, including Web of Science<sup>®</sup> (Thomson Reuters, USA), PubMed<sup>®</sup> (U.S. National Library of Medicine, USA), and SciVerse Scopus<sup>®</sup> (Elsevier Properties S.A., USA), taking into consideration certain search terms like \\\"breast cancer,\\\" \\\"natural products against breast cancer,\\\" and \\\"Clinically proven natural products in the treatment of breast cancer\\\" and so on.</p><p><strong>Results: </strong>Several natural products, namely Omega-3 fatty acids, dietary isothiocyanates, curcumin, green tea, flaxseed, limonene, and others, were found to modulate crucial pathways in breast cancer cells. 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引用次数: 0
摘要
背景:乳腺癌仍然是全球女性癌症相关发病率和死亡率的首要因素,约占全球女性癌症相关死亡人数的14%。本研究旨在阐明天然产品抗乳腺癌治疗的机制和临床发现。方法:这篇综述文章所需的数据是通过几个容易获得的搜索数据库检索的,包括Web of Science®(Thomson Reuters,美国)、PubMed®(美国国家医学图书馆,美国)和SciVerse Scopus®(Elsevier Properties s.a.,美国),并考虑到某些搜索词,如“乳腺癌”、“抗乳腺癌的天然产品”和“临床证明的治疗乳腺癌的天然产品”等。结果:几种天然产物,即Omega-3脂肪酸、膳食异硫氰酸酯、姜黄素、绿茶、亚麻籽、柠檬烯等,被发现可以调节乳腺癌细胞的关键途径。这些物质通过下调血管内皮生长因子(VEGF)抑制血管生成,通过激活caspase促进细胞凋亡,通过控制细胞周期蛋白依赖性激酶阻止细胞增殖。临床研究表明,采用标准治疗程序接受这些天然产物的患者的预后得到改善。讨论:研究结果强调了天然产物在乳腺癌治疗中的多方面功能,强调了它们在提高常规治疗效果的同时减少不良反应的潜力。需要进一步探索协同作用和最佳剂量。结论:临床证实的天然产品代表了乳腺癌治疗的潜在途径,其机制见解有助于将其纳入治疗方案。为了使临床应用最大化,未来的研究应集中在阐明这些抗癌功能的全谱上。
Clinically proven natural products against breast cancer, with mechanistic insights.
Background: Breast cancer still stands to be the foremost contributor to cancer-related incidence and mortality in women globally accounting for about 14% of all female cancer-related deaths worldwide. This research seeks to illustrate the mechanisms and clinical findings of natural products against breast cancer treatment.
Methodology: Required data for this review article was retrieved employing several readily obtainable search databases, including Web of Science® (Thomson Reuters, USA), PubMed® (U.S. National Library of Medicine, USA), and SciVerse Scopus® (Elsevier Properties S.A., USA), taking into consideration certain search terms like "breast cancer," "natural products against breast cancer," and "Clinically proven natural products in the treatment of breast cancer" and so on.
Results: Several natural products, namely Omega-3 fatty acids, dietary isothiocyanates, curcumin, green tea, flaxseed, limonene, and others, were found to modulate crucial pathways in breast cancer cells. These substances suppressed angiogenesis by downregulating the vascular endothelial growth factor (VEGF), promoted apoptosis by activating caspase enzymes, and prevented cell proliferation by controlling cyclin-dependent kinases. Clinical studies demonstrated improved outcomes in patients receiving these natural products with standard treatment procedures.
Discussion: The findings underscore the multifaceted functions of natural products in breast cancer therapy, highlighting their potential to increase the efficacy of conventional treatments while reducing adverse effects. Further exploration of synergistic actions and optimal dosages is needed.
Conclusion: Clinically proven natural products represent a potential avenue for breast cancer treatment with their mechanistic insights that facilitate their incorporation into treatment regimens. To maximize clinical applications, future inquiries should center on elucidating the full spectrum of these anticancer functions.
期刊介绍:
Oncology Research Featuring Preclinical and Clincal Cancer Therapeutics publishes research of the highest quality that contributes to an understanding of cancer in areas of molecular biology, cell biology, biochemistry, biophysics, genetics, biology, endocrinology, and immunology, as well as studies on the mechanism of action of carcinogens and therapeutic agents, reports dealing with cancer prevention and epidemiology, and clinical trials delineating effective new therapeutic regimens.