组学技术在神经网络研究中的应用。

IF 4.6 2区医学 Q1 NEUROSCIENCES

Experimental Neurology Pub Date : 2025-07-01 DOI:10.1016/j.expneurol.2025.115369

Sihan Huang , Jiao Tang , Xiao Wu , Huan Xu , Sihui Li , Hongying Li , Siyu Zhang , Guangxin Xie , Tingyu Wang , Xincheng Pan , Ahmad Fasih , Maochun You , Zhanqiong Zhong , Lushuang Xie , Qiaofeng Wu , Shuguang Yu

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引用次数: 0

摘要

神经退行性疾病（NDs）是以中枢神经系统（CNS）神经元变性为特征的进行性疾病，最终导致神经功能障碍。神经退行性进展通常与神经周围网络（PNNs）的结构和功能改变有关。随着测序技术和组学学科的不断进步，许多技术被广泛应用于pnn的研究。对pnn的研究有助于认识nd的发病机制和临床诊断，寻找新的药物治疗靶点。在本文中，我们关注了这些组学技术在pnn中的应用，并总结了NDs中pnn的一些变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The omics techniques used in perineuronal nets research

Neurodegenerative diseases (NDs) are progressive disorders characterized by neuronal degeneration in the central nervous system (CNS), ultimately leading to neurological dysfunction. Neurodegenerative progression is often associated with structural and functional alterations in perineuronal nets (PNNs). With the continuous advancement of sequencing technologies and omics disciplines, numerous techniques have been widely applied to studies on PNNs. Research on PNNs is beneficial for understanding the pathogenesis and clinical diagnosis of NDs and finding new drug treatment targets. In this review, we paid attention to these omics technologies used in PNNs and also summarized some alterations in PNNs in NDs.

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.